Protein S100 Beta as a Predictor of Resuscitation Outcome
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ClinicalTrials.gov Identifier: NCT00814814 |
Recruitment Status
:
Active, not recruiting
First Posted
: December 25, 2008
Last Update Posted
: April 28, 2017
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Management of cardiac arrest is complicated by the lack of a readily available tool identifying individuals who are likely to be successfully resuscitated. S100 beta is a protein that originates in the astroglial cells of the brain, and NSE (Neuron Specific Enolase) is another protein that originates in the neurons themselves. In the laboratory, the concentration of these proteins correlate with evidence of brain damage after head trauma, stroke and exposure to low levels of oxygen. The concentration of these proteins in the blood of human survivors of cardiopulmonary resuscitation in humans is much higher than in patients who were resuscitated but did not survive. However, it is still unclear whether survivors from cardiopulmonary resuscitation have higher levels of these proteins in their blood if they survive with neurological injury secondary to the arrest and resuscitation.
Hypothesis: In humans, the blood concentrations of protein S100 beta and NSE during and after resuscitation can predict who will die despite cardiopulmonary resuscitation and who will survive with neurological injury secondary to the arrest and resuscitation.
Condition or disease |
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Cardiopulmonary Arrest Outcome |
Study Type : | Observational |
Actual Enrollment : | 313 participants |
Observational Model: | Cohort |
Time Perspective: | Other |
Official Title: | Protein S100 Beta as a Predictor of the Outcome of Cardiopulmonary Resuscitation |
Study Start Date : | August 2008 |
Estimated Primary Completion Date : | March 2019 |
Estimated Study Completion Date : | September 2020 |
Group/Cohort |
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Cardiopulmonary arrest |
- Poor versus good patient outcome at discharge was used to test the study hypotheses of improved prediction attributable to S100B and NSE concentration. [ Time Frame: within 24 hours of discharge ]
Biospecimen Retention: Samples With DNA

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Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
Inclusion Criteria:
- All victims of non-traumatic out-of hospital cardiopulmonary arrest (defined as the absence of either spontaneous respiration or palpable pulse or both) within the Jerusalem district.
Exclusion Criteria:
- Patients with do-not-resuscitate orders or an advance directive to that effect.
- Patients with intracranial hemorrhage

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00814814
Israel | |
Shaare Zedek Medical Center | |
Jerusalem, Israel, 91031 | |
Hadassah Medical Center | |
Jerusalem, Israel, 91120 |
Principal Investigator: | Sharon Einav, MD | Shaare Zedek Medical Center |
Publications of Results:
Responsible Party: | Dr Sharon Einav, Dr., Shaare Zedek Medical Center |
ClinicalTrials.gov Identifier: | NCT00814814 History of Changes |
Other Study ID Numbers: |
14-01-05 A and B (correction) |
First Posted: | December 25, 2008 Key Record Dates |
Last Update Posted: | April 28, 2017 |
Last Verified: | April 2017 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | Yes |
Additional relevant MeSH terms:
Heart Arrest Heart Diseases Cardiovascular Diseases Protein S Anticoagulants |