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Glycosaminoglycans During Septic Shock - a Temporal Study (GAGS)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified October 2009 by Region Skane.
Recruitment status was:  Recruiting
Information provided by:
Region Skane Identifier:
First received: December 22, 2008
Last updated: October 7, 2009
Last verified: October 2009
We have previously shown that the plasma level of glycosaminoglycans (GAG) in septic shock patients are elevated compared to controls. The purpose of this study is to investigate the temporal dynamic of the blood level of GAG in ten septic shock patients. In addition, to assess the kinetics of GAG during septic shock we examine the liver function by galactose elimination capacity as well as excreted urinary GAG.

Septic Shock

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: GAGS - Glykosaminoglykaner Vid Sepsis

Resource links provided by NLM:

Further study details as provided by Region Skane:

Biospecimen Retention:   Samples Without DNA
Plasma and Urine.

Estimated Enrollment: 20
Study Start Date: November 2008
Estimated Primary Completion Date: November 2010 (Final data collection date for primary outcome measure)
1 septic shock
septic shock, ICU
2 controls
matched controls


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Septic Shock

Inclusion Criteria:

  • 2 out of 4 SIRS criteria, where the circulatory criteria must be fulfilled
  • Clinical sepsis is suspected
  • Informed consent from relative
  • Study subject must be over 18 years old

Exclusion Criteria:

  • Pregnancy
  • >24h post sepsis diagnosis
  • Ongoing oral or intravenous cortisone treatment for more than one month.
  • Malignancy with metastasis
  Contacts and Locations
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Please refer to this study by its identifier: NCT00814112

Contact: Ingrid Berkestedt, MD PhD +4646171949
Contact: Axel Nelson, PhD-student

Intensive Care Unit, Lund University Hospital Recruiting
Lund, Sweden, 22185
Contact: Ingrid Berkestedt, MD PhD    +4646171949   
Sub-Investigator: Axel Nelson, PhD student         
Sub-Investigator: Ingrid Berkestedt, MD PhD         
Sponsors and Collaborators
Region Skane
Principal Investigator: Mikael Bodelsson, professor Intensive Care Unit, Lund University Hospital, Sweden
  More Information

Responsible Party: Mikael Bodelsson/Professor, Lund University Hospital Identifier: NCT00814112     History of Changes
Other Study ID Numbers: GAGS 293/2008
Study First Received: December 22, 2008
Last Updated: October 7, 2009

Additional relevant MeSH terms:
Shock, Septic
Pathologic Processes
Systemic Inflammatory Response Syndrome
Inflammation processed this record on September 21, 2017