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Effect of β-alanine Supplementation on Muscle Carnosine (LitmusMagnet)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00813553
Recruitment Status : Completed
First Posted : December 23, 2008
Last Update Posted : April 25, 2012
Sponsor:
Collaborators:
Information provided by (Responsible Party):

Study Description
Brief Summary:
Carnosine is a natural acid buffering substance of muscle. The primary objective of this study is to test whether a nutritional supplement of beta-alanine enhances carnosine content in muscle.

Condition or disease Intervention/treatment
Healthy Dietary Supplement: placebo Dietary Supplement: beta-alanine

Detailed Description:
Volunteers will be randomized to receiving 3 nutritional supplements. Two supplements contain beta-alanine at different doses, the third supplement is a placebo.

Study Design

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 30 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Official Title: Effect of Two 8-week β-alanine Supplementation Protocols on Muscle Carnosine
Study Start Date : December 2008
Primary Completion Date : October 2009
Study Completion Date : October 2009

Resource links provided by the National Library of Medicine

Drug Information available for: Alanine
U.S. FDA Resources

Arms and Interventions

Arm Intervention/treatment
Placebo Comparator: beta-alanine 0 Dietary Supplement: placebo
daily
Experimental: beta-alanine 1 Dietary Supplement: beta-alanine
daily
Experimental: beta-alanine 2 Dietary Supplement: beta-alanine
daily


Outcome Measures

Primary Outcome Measures :
  1. muscle carnosine concentration [ Time Frame: 0 to 8 weeks ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Stable health as evaluated by medical evaluation
  • Body mass index higher than 18 kg/m2
  • Body mass index lower than 25 kg/m2, unless body fat is less than 20%

Exclusion Criteria:

  • intolerance to β-alanine,
  • allergy to soy, fish and crustacean
  • participation in another intervention study
  • consumer of dietary supplement susceptible to contain beta-alanine
  • determined to have very high baseline muscle carnosine concentration
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00813553


Locations
Switzerland
University and Inselspital
Bern, Switzerland, 3010
Sponsors and Collaborators
Nestlé
University of Bern
University Hospital Inselspital, Berne
More Information

Responsible Party: Nestlé
ClinicalTrials.gov Identifier: NCT00813553     History of Changes
Other Study ID Numbers: 08.13.PER
First Posted: December 23, 2008    Key Record Dates
Last Update Posted: April 25, 2012
Last Verified: April 2012

Keywords provided by Nestlé:
physical fitness
exercise
amino acid