This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Effect of β-alanine Supplementation on Muscle Carnosine (LitmusMagnet)

This study has been completed.
University of Bern
University Hospital Inselspital, Berne
Information provided by (Responsible Party):
Nestlé Identifier:
First received: December 22, 2008
Last updated: April 24, 2012
Last verified: April 2012
Carnosine is a natural acid buffering substance of muscle. The primary objective of this study is to test whether a nutritional supplement of beta-alanine enhances carnosine content in muscle.

Condition Intervention
Healthy Dietary Supplement: placebo Dietary Supplement: beta-alanine

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Official Title: Effect of Two 8-week β-alanine Supplementation Protocols on Muscle Carnosine

Resource links provided by NLM:

Further study details as provided by Nestlé:

Primary Outcome Measures:
  • muscle carnosine concentration [ Time Frame: 0 to 8 weeks ]

Estimated Enrollment: 30
Study Start Date: December 2008
Study Completion Date: October 2009
Primary Completion Date: October 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Placebo Comparator: beta-alanine 0 Dietary Supplement: placebo
Experimental: beta-alanine 1 Dietary Supplement: beta-alanine
Experimental: beta-alanine 2 Dietary Supplement: beta-alanine

Detailed Description:
Volunteers will be randomized to receiving 3 nutritional supplements. Two supplements contain beta-alanine at different doses, the third supplement is a placebo.

Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Stable health as evaluated by medical evaluation
  • Body mass index higher than 18 kg/m2
  • Body mass index lower than 25 kg/m2, unless body fat is less than 20%

Exclusion Criteria:

  • intolerance to β-alanine,
  • allergy to soy, fish and crustacean
  • participation in another intervention study
  • consumer of dietary supplement susceptible to contain beta-alanine
  • determined to have very high baseline muscle carnosine concentration
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00813553

University and Inselspital
Bern, Switzerland, 3010
Sponsors and Collaborators
University of Bern
University Hospital Inselspital, Berne
  More Information

Responsible Party: Nestlé Identifier: NCT00813553     History of Changes
Other Study ID Numbers: 08.13.PER
Study First Received: December 22, 2008
Last Updated: April 24, 2012

Keywords provided by Nestlé:
physical fitness
amino acid processed this record on August 18, 2017