Study of Gulf War Illness (GWI) by Comparing GWI and Healthy Veterans

This study has been completed.
U.S. Army Medical Research and Materiel Command
Information provided by (Responsible Party):
James Baraniuk, MD, Georgetown University Identifier:
First received: December 17, 2008
Last updated: February 24, 2014
Last verified: February 2014

Determine if:

  • genetic differences of CNDP1 gene
  • the previously defined GWI/Chronic Fatigue Syndrome (GWI/CFS) cerebrospinal fluid proteome contents
  • psychometric
  • other variables can differentiate between veterans of the 1990-1991 Persian Gulf War who have autonomic, neurological and other symptoms and those without these complaints.

Gulf War Illness
Persian Gulf War Syndrome

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: CNDP1 Polymorphisms in Gulf War Illness (GWI)

Further study details as provided by Georgetown University:

Biospecimen Retention:   Samples With DNA
Plasma, serum, urine, and buccal swab samples retained for testing as described in protocol.

Estimated Enrollment: 516
Study Start Date: August 2008
Study Completion Date: July 2011
Primary Completion Date: July 2011 (Final data collection date for primary outcome measure)
GWI: veterans of the 1990-1991 Persian Gulf War who have autonomic, neurological and other symptoms
HC: healthy veterans of the 1990-1991 Persian Gulf War


Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
All veterans who served in the Armed Forces between August 1990 and July 1991

Inclusion Criteria:

  • Evidence of military enlistment between August 1, 1990 and July 31, 1991, and deployment for 30 consecutive days to:

    • Persian Gulf waters and adjacent land areas
    • Other global locations
    • U.S. only
  • Status prior to 1990 and 1991:

    • Active duty
    • National Guard
    • Reserves

Exclusion Criteria:

  • Current active duty military personnel
  • Any one who was not active duty military personnel between August 1, 1990 and July 31, 1991
  • HIV/AIDS; pregnancy or lactation; potential hepatitis; drug addiction; chronic inflammatory, infectious, or autoimmune medical illnesses not associated with GWI; incarceration; dementia, other cognitive limitation; or reliance on a care-giver in order to respond to the questionnaires and other study tests.

Amputations of one or both hands and forearms will be permitted but hand grip tests will not be tested

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Please refer to this study by its identifier: NCT00810225

United States, District of Columbia
Georgetown University
Washington, District of Columbia, United States, 20007
Sponsors and Collaborators
Georgetown University
U.S. Army Medical Research and Materiel Command
Principal Investigator: James N Baraniuk, MD Georgetown University
  More Information

Additional Information:
Responsible Party: James Baraniuk, MD, Professor of Medicine, Georgetown University Identifier: NCT00810225     History of Changes
Other Study ID Numbers: 2008-012  USAMRMC PR# W81XWH-07-1-0618  HRPO Log No. A-14542.1 
Study First Received: December 17, 2008
Last Updated: February 24, 2014
Health Authority: United States: Institutional Review Board
United States: Federal Government

Keywords provided by Georgetown University:
carnosine dipeptidase 1
Persian Gulf War
Gulf War Syndrome
Gulf War Illness
Chronic Fatigue
Irritable Bowel Syndrome
Migraine headaches
Multiple Chemical Sensitivity

Additional relevant MeSH terms:
Persian Gulf Syndrome
Occupational Diseases processed this record on May 26, 2016