Bioavailability and Metabolism of Anthocyanins Following Acute Cranberry Consumption
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|ClinicalTrials.gov Identifier: NCT00809900|
Recruitment Status : Completed
First Posted : December 17, 2008
Last Update Posted : December 2, 2009
|Condition or disease||Intervention/treatment|
|Bioavailability Cardiovascular Disease||Dietary Supplement: Experimental|
Little is known about the acute or chronic pharmacokinetics and metabolism of anthocyanins consumed in amounts relevant to usual dietary intakes. Thus, we hypothesize that anthocyanins from a single oral dose of cranberry juice will be absorbed quickly and can be measured in the circulation and urine within 2-4 h. Further, these anthocyanins will undergo a degree of metabolism but will circulate as well as be removed from blood as both parent compounds and metabolic products.
This research proposal is submitted as an independent sub-study of an existing project, "Effects of Cranberry Juice on Endothelial Function in Patients with Coronary Artery Disease", conducted by Joseph A. Vita, MD at the Boston University School of Medicine and sponsored by Ocean Spray Cranberries, Inc.
This study includes 15 subjects aged 21-80 y and with demonstrated endothelial dysfunction and angiographically proven coronary artery disease who will receive a single dose of 480 mL cranberry juice.
To test the hypotheses of the study to be conducted at HNRCA Tufts, we will utilize blood and urine samples that are already collected and stored. We will separate and analyze anthocyanins in these samples by HPLC and determine the pharmacokinetics of relevant anthocyanins.
|Study Type :||Observational|
|Actual Enrollment :||15 participants|
|Official Title:||Bioavailability and Metabolism of Anthocyanins Following Acute Cranberry (Vaccinium Macrocarpon)Consumption|
|Study Start Date :||June 2007|
|Actual Primary Completion Date :||April 2008|
|Actual Study Completion Date :||April 2008|
Cranberry Juice Consumption
Dietary Supplement: Experimental
Administration of of 480 mL cranberry juice
Other Name: Cranberry Juice
- Anthocyanin levels in plasma and urine [ Time Frame: 0, 2, and 4 hours ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00809900
|United States, Massachusetts|
|Jean Mayer USDA Human Nutrition Center on Aging at Tufts University|
|Boston, Massachusetts, United States, 02111|
|Principal Investigator:||Paul E. Milbury, Ph.D.||Tufts University|