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Effects of Dietary Proteins on Postprandial Lipaemia and Incretin Responses in Obese Subjects

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00809874
First Posted: December 17, 2008
Last Update Posted: November 10, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
The Danish Obesity Research Centre
Nordic Centre of Excellence
Arla Foods
Information provided by:
Aarhus University Hospital
  Purpose

The purpose of this study is to determine the effects of dietary protein on blood lipids and gut hormones after a fat-rich meal.

Hypothesis: Certain dietary proteins reduce the amount of fat circulating in the blood stream following a fat rich meal. The effect is dependant of both the quality and the quantity of protein ingested.


Condition Intervention
Postprandial Lipaemia Postprandial Incretins Postprandial Inflammation Dietary Supplement: Casein Dietary Supplement: Whey Isolate Dietary Supplement: Whey Hydrolysate Dietary Supplement: Alphalact-Albumin

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Effects of Dietary Proteins on Postprandial Lipaemia and Incretin Responses in Obese Subjects

Resource links provided by NLM:


Further study details as provided by Aarhus University Hospital:

Primary Outcome Measures:
  • Triglyceride [ Time Frame: 0h- 1h- 2h- 4h- 6h- 7h- 8h postprandial ]

Secondary Outcome Measures:
  • Incretins [ Time Frame: 0h -1h -2h -4h -6h -7h -8h Postprandial ]

Enrollment: 11
Study Start Date: February 2008
Study Completion Date: December 2008
Primary Completion Date: December 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Casein Dietary Supplement: Casein
Active Comparator: Whey Isolate Dietary Supplement: Whey Isolate
Active Comparator: Whey Hydrolysate Dietary Supplement: Whey Hydrolysate
Active Comparator: Alphalact-Albumin Dietary Supplement: Alphalact-Albumin

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • BMI >30 kg/m2 & <45 kg/m2

Exclusion Criteria:

  • Diabetes
  • lipid lowering drugs
  • Liver-, Kidney- and/or Heart Disease
  • Serious Hypertension (160/110)
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00809874


Locations
Denmark
Department of Clinical Nutrion
Aarhus, Denmark, 8000
Sponsors and Collaborators
Aarhus University Hospital
The Danish Obesity Research Centre
Nordic Centre of Excellence
Arla Foods
Investigators
Principal Investigator: K Hermansen, Professor, MD Department of Endocrinology and Metabolism, Aarhus University Hospital
  More Information

Responsible Party: Kjeld Hermansen, Professor, Chief Physician, MD, Dr.Med.Sci, Department of Endocrinology And Metabolism, Aarhus University Hospital
ClinicalTrials.gov Identifier: NCT00809874     History of Changes
Other Study ID Numbers: CERN-PPL-JHJ
First Submitted: December 16, 2008
First Posted: December 17, 2008
Last Update Posted: November 10, 2009
Last Verified: November 2009

Keywords provided by Aarhus University Hospital:
Postprandial Period
Postprandial Lipaemia
Incretins
Subclinical Inflammation
Obesity
Atherosclerosis
Triglyceride
Lipoproteins

Additional relevant MeSH terms:
Inflammation
Hyperlipidemias
Pathologic Processes
Dyslipidemias
Lipid Metabolism Disorders
Metabolic Diseases
Incretins
Caseins
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Chelating Agents
Sequestering Agents
Molecular Mechanisms of Pharmacological Action