Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Effects of Dietary Proteins on Postprandial Lipaemia and Incretin Responses in Obese Subjects

This study has been completed.
The Danish Obesity Research Centre
Nordic Centre of Excellence
Arla Foods
Information provided by:
Aarhus University Hospital Identifier:
First received: December 16, 2008
Last updated: November 9, 2009
Last verified: November 2009

The purpose of this study is to determine the effects of dietary protein on blood lipids and gut hormones after a fat-rich meal.

Hypothesis: Certain dietary proteins reduce the amount of fat circulating in the blood stream following a fat rich meal. The effect is dependant of both the quality and the quantity of protein ingested.

Condition Intervention
Postprandial Lipaemia
Postprandial Incretins
Postprandial Inflammation
Dietary Supplement: Casein
Dietary Supplement: Whey Isolate
Dietary Supplement: Whey Hydrolysate
Dietary Supplement: Alphalact-Albumin

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: Effects of Dietary Proteins on Postprandial Lipaemia and Incretin Responses in Obese Subjects

Resource links provided by NLM:

Further study details as provided by Aarhus University Hospital:

Primary Outcome Measures:
  • Triglyceride [ Time Frame: 0h- 1h- 2h- 4h- 6h- 7h- 8h postprandial ]

Secondary Outcome Measures:
  • Incretins [ Time Frame: 0h -1h -2h -4h -6h -7h -8h Postprandial ]

Enrollment: 11
Study Start Date: February 2008
Study Completion Date: December 2008
Primary Completion Date: December 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Casein Dietary Supplement: Casein
Active Comparator: Whey Isolate Dietary Supplement: Whey Isolate
Active Comparator: Whey Hydrolysate Dietary Supplement: Whey Hydrolysate
Active Comparator: Alphalact-Albumin Dietary Supplement: Alphalact-Albumin


Ages Eligible for Study:   40 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • BMI >30 kg/m2 & <45 kg/m2

Exclusion Criteria:

  • Diabetes
  • lipid lowering drugs
  • Liver-, Kidney- and/or Heart Disease
  • Serious Hypertension (160/110)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00809874

Department of Clinical Nutrion
Aarhus, Denmark, 8000
Sponsors and Collaborators
Aarhus University Hospital
The Danish Obesity Research Centre
Nordic Centre of Excellence
Arla Foods
Principal Investigator: K Hermansen, Professor, MD Department of Endocrinology and Metabolism, Aarhus University Hospital
  More Information

Responsible Party: Kjeld Hermansen, Professor, Chief Physician, MD, Dr.Med.Sci, Department of Endocrinology And Metabolism, Aarhus University Hospital Identifier: NCT00809874     History of Changes
Other Study ID Numbers: CERN-PPL-JHJ
Study First Received: December 16, 2008
Last Updated: November 9, 2009

Keywords provided by Aarhus University Hospital:
Postprandial Period
Postprandial Lipaemia
Subclinical Inflammation

Additional relevant MeSH terms:
Pathologic Processes
Lipid Metabolism Disorders
Metabolic Diseases
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Chelating Agents
Sequestering Agents
Molecular Mechanisms of Pharmacological Action processed this record on May 25, 2017