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Frozen Embryo Transfer (FET) in Natural Cycles or in Natural Cycles Controlled by Human Chorionic Gonadotropin (hCG) Administration (FRET)

This study has been completed.
Information provided by:
Universitair Ziekenhuis Brussel Identifier:
First received: December 16, 2008
Last updated: February 18, 2009
Last verified: February 2009
The rational of the study is to assess the implantation, pregnancy and live birth rates after the transfer of frozen- thawed embryos in natural cycles with spontaneous Luteinizing Hormone (LH)/Progesterone rise or in natural cycles controlled by human chorionic gonadotropin (hCG) for final oocyte maturation and ovulation.

Condition Intervention
Infertility Drug: HCG

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Cryopreserved-Thawed Embryo Transfer in Natural Cycle or in Natural Cycles Controlled by External Administration of hCG: a Prospective Randomized Study

Resource links provided by NLM:

Further study details as provided by Universitair Ziekenhuis Brussel:

Primary Outcome Measures:
  • Implantation rate [ Time Frame: 2 years ]

Secondary Outcome Measures:
  • Ongoing pregnancy rate [ Time Frame: 2 years ]

Estimated Enrollment: 150
Study Start Date: October 2006
Study Completion Date: January 2009
Primary Completion Date: July 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
Drug: HCG
Other Name: pregnyl
No Intervention: 2
LH pick


Ages Eligible for Study:   17 Years to 40 Years   (Child, Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • age <40
  • BMI:18-29Kg/m2
  • day 3 embryo transfers
  • previously IVF or ICSI

Exclusion Criteria:

  • irregular cycles
  • oocyte donation cycles
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00809107

Centre of Reproductive Medicine
Brussel, Belgium, 1090
Sponsors and Collaborators
Universitair Ziekenhuis Brussel
  More Information

Responsible Party: Kyrou Dimitra, centre of reproductive medicine-UZ Identifier: NCT00809107     History of Changes
Other Study ID Numbers: TC3471
Study First Received: December 16, 2008
Last Updated: February 18, 2009

Keywords provided by Universitair Ziekenhuis Brussel:
natural cycle
spontaneous LH pic

Additional relevant MeSH terms:
Genital Diseases, Male
Genital Diseases, Female
Chorionic Gonadotropin
Reproductive Control Agents
Physiological Effects of Drugs processed this record on July 26, 2017