Frozen Embryo Transfer (FET) in Natural Cycles or in Natural Cycles Controlled by Human Chorionic Gonadotropin (hCG) Administration (FRET)

This study has been completed.
Information provided by:
Universitair Ziekenhuis Brussel Identifier:
First received: December 16, 2008
Last updated: February 18, 2009
Last verified: February 2009
The rational of the study is to assess the implantation, pregnancy and live birth rates after the transfer of frozen- thawed embryos in natural cycles with spontaneous Luteinizing Hormone (LH)/Progesterone rise or in natural cycles controlled by human chorionic gonadotropin (hCG) for final oocyte maturation and ovulation.

Condition Intervention
Drug: HCG

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Cryopreserved-Thawed Embryo Transfer in Natural Cycle or in Natural Cycles Controlled by External Administration of hCG: a Prospective Randomized Study

Resource links provided by NLM:

Further study details as provided by Universitair Ziekenhuis Brussel:

Primary Outcome Measures:
  • Implantation rate [ Time Frame: 2 years ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • Ongoing pregnancy rate [ Time Frame: 2 years ] [ Designated as safety issue: Yes ]

Estimated Enrollment: 150
Study Start Date: October 2006
Study Completion Date: January 2009
Primary Completion Date: July 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
Drug: HCG
Other Name: pregnyl
No Intervention: 2
LH pick


Ages Eligible for Study:   17 Years to 40 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • age <40
  • BMI:18-29Kg/m2
  • day 3 embryo transfers
  • previously IVF or ICSI

Exclusion Criteria:

  • irregular cycles
  • oocyte donation cycles
  Contacts and Locations
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Please refer to this study by its identifier: NCT00809107

Centre of Reproductive Medicine
Brussel, Belgium, 1090
Sponsors and Collaborators
Universitair Ziekenhuis Brussel
  More Information

Responsible Party: Kyrou Dimitra, centre of reproductive medicine-UZ Identifier: NCT00809107     History of Changes
Other Study ID Numbers: TC3471
Study First Received: December 16, 2008
Last Updated: February 18, 2009
Health Authority: Belgium: Institutional Review Board

Keywords provided by Universitair Ziekenhuis Brussel:
natural cycle
spontaneous LH pic

Additional relevant MeSH terms:
Chorionic Gonadotropin
Pharmacologic Actions
Physiological Effects of Drugs
Reproductive Control Agents
Therapeutic Uses processed this record on November 27, 2015