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Leucine Supplementation in Elderly Men

This study has been completed.
Information provided by:
Maastricht University Medical Center Identifier:
First received: December 11, 2008
Last updated: NA
Last verified: December 2008
History: No changes posted
In the present study the investigators aim to determine whether leucine supplementation can augment muscle mass and strength and improve body composition in healthy elderly men

Condition Intervention Phase
Sarcopenia Atrophy Aging Dietary Supplement: placebo Dietary Supplement: leucine Phase 1 Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: The Influence of Leucine Supplementation on Body Composition and Muscle Characteristics in Healthy Elderly

Resource links provided by NLM:

Further study details as provided by Maastricht University Medical Center:

Primary Outcome Measures:
  • muscle mass and body composition [ Time Frame: before and after 12 wk intervention ]

Secondary Outcome Measures:
  • muscle strength [ Time Frame: before and after 12 wk intervention ]

Enrollment: 29
Study Start Date: January 2007
Study Completion Date: December 2008
Primary Completion Date: December 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
daily leucine supplementation
Dietary Supplement: leucine
daily leucine capsules with each main meal
Placebo Comparator: 2
daily placebo supplementation
Dietary Supplement: placebo
wheat meal capsules with each main meal


Ages Eligible for Study:   65 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • living independently

Exclusion Criteria:

  • Diabetes cardiovascular disease orthopedic limitations history of resistance training in past 5 years
  Contacts and Locations
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Please refer to this study by its identifier: NCT00807508

Maastricht University Medical Centre
Maastricht, Netherlands, 6200 MD
Sponsors and Collaborators
Maastricht University Medical Center
Principal Investigator: Luc JC van Loon, PhD Maastricht University Medical Center
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Luc JC van Loon, PhD, MaastrichtUMC Identifier: NCT00807508     History of Changes
Other Study ID Numbers: MEC 06-3-062A
Study First Received: December 11, 2008
Last Updated: December 11, 2008

Additional relevant MeSH terms:
Pathological Conditions, Anatomical
Muscular Atrophy
Neuromuscular Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms processed this record on August 23, 2017