Transbronchial Catheter Aspiration and Transbronchial Needle Aspiration in the Diagnosis of Lung Cancer
The aim of this study is prospectively to determine the diagnostic sensitivity of Transbronchial Catheter Aspiration (TBCA) in comparison with Transbronchial Needle Aspiration (TBNA) in the diagnosis of peripheral nodules and masses of the lung.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Diagnostic
|Official Title:||Transbronchial Catheter Aspiration Compared to Transbronchial Needle Aspiration in the Diagnosis of Peripheral Nodules and Masses of the Lung|
- Diagnostic sensitivity of transbronchial catheter aspiration in comparison with transbronchial needle aspiration. [ Time Frame: one year ] [ Designated as safety issue: No ]
- Yield by combination of the applied techniques [ Time Frame: one year ] [ Designated as safety issue: No ]
|Study Start Date:||July 2009|
|Study Completion Date:||November 2010|
|Primary Completion Date:||November 2010 (Final data collection date for primary outcome measure)|
Under fluoroscopy first transbronchial forceps biopsy is performed, afterwards in random order transbronchial catheter aspiration(TBCA) and transbronchial needle aspiration (TBNA).
Procedure: TBCA, TBNA
One arm, in random order first transbronchial catheter aspiration and second transbronchial needle aspiration or vice verse, both techniques routinely used in the diagnosis of peripheral pulmonary lesions; the cytological specimens of TBCA and TBNA are in random order examined by two independent cytologists, all cytological specimens are afterwards examined by a third, supervising cytologist.
Other Name: transbronchial biopsy
The yield of transbronchial forceps biopsy under fluoroscopy in the diagnosis of peripheral lesion of the lung lies between 32 and 57%. Several studies prove an amelioration of success rates by addition of cytological methods such as TBNA, TBCA and bronchial brushing. Furthermore, for TBNA and TBCA a significantly higher yield was reported in comparison with transbronchial forceps biopsy. TBNA and TBCA are routinely used methods, both techniques are safe, the instruments used are certificated.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00807391
|Universitätsklinikum Essen, Institut für Pathologie|
|Essen, NRW, Germany, 45122|
|Helios Klinik Ambrock, Department of Pneumology and Critical Care Medicine|
|Hagen, NRW, Germany, 58091|
|Principal Investigator:||Karl-Josef Franke, MD||Helios Klinik Ambrock|