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Examination of B Cell Responses in Human Blood

This study has been completed.
University of Leipzig
Information provided by (Responsible Party):
Christian Jassoy, Regenerative Medicine Network Identifier:
First received: December 10, 2008
Last updated: May 12, 2015
Last verified: May 2015
The aim of this study is the assessment B-cell immune responses in HIV-infected individuals.

HIV Infections

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Gewinnung Humaner antikörperproduzierender Zellen Aus Dem Blut

Resource links provided by NLM:

Further study details as provided by Regenerative Medicine Network:

Primary Outcome Measures:
  • Antigen specific B-cell responses [ Time Frame: 18 months ]

Biospecimen Retention:   Samples Without DNA
peripheral blood

Enrollment: 50
Study Start Date: July 2008
Study Completion Date: February 2010
Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
HIV infected individuals, HIV controllers
CD4+ T cell count > 350/µl, HIV load < 1000 copies/ml
HIV infected individuals, early progressors
CD4+ T cell count > 350/µl, HIV load > 1000 copies/ml
HIV infected individuals, late progressors
CD4+ T cell count < 200/µl
HIV infected individuals, late progressors with therapy
CD4+ T cell count < 200/µl, under ART
Healthy individuals

Detailed Description:
Groups of patients with different immune competencies will be examined. The impact of HIV infection on immune response will be assessed.

Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
HIV patients and controls attending specialised clinics, Germany

Inclusion Criteria:

  • HIV-infected individuals
  • controls

Exclusion Criteria:

- none

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Please refer to this study by its identifier: NCT00806845

Universität Leipzig
Leipzig, Sachsen, Germany, 04103
Sponsors and Collaborators
Regenerative Medicine Network
University of Leipzig
Study Director: Christian Jassoy, MD Universität Leipzig
  More Information

Responsible Party: Christian Jassoy, Professor of Virology, Regenerative Medicine Network Identifier: NCT00806845     History of Changes
Other Study ID Numbers: RegMedNet-001
Study First Received: December 10, 2008
Last Updated: May 12, 2015

Keywords provided by Regenerative Medicine Network:

Additional relevant MeSH terms:
HIV Infections
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases processed this record on May 23, 2017