Examination of B Cell Responses in Human Blood

This study has been completed.
University of Leipzig
Information provided by (Responsible Party):
Christian Jassoy, Regenerative Medicine Network
ClinicalTrials.gov Identifier:
First received: December 10, 2008
Last updated: May 12, 2015
Last verified: May 2015
The aim of this study is the assessment B-cell immune responses in HIV-infected individuals.

HIV Infections

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Gewinnung Humaner antikörperproduzierender Zellen Aus Dem Blut

Resource links provided by NLM:

Further study details as provided by Regenerative Medicine Network:

Primary Outcome Measures:
  • Antigen specific B-cell responses [ Time Frame: 18 months ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA
peripheral blood

Enrollment: 50
Study Start Date: July 2008
Study Completion Date: February 2010
Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
HIV infected individuals, HIV controllers
CD4+ T cell count > 350/µl, HIV load < 1000 copies/ml
HIV infected individuals, early progressors
CD4+ T cell count > 350/µl, HIV load > 1000 copies/ml
HIV infected individuals, late progressors
CD4+ T cell count < 200/µl
HIV infected individuals, late progressors with therapy
CD4+ T cell count < 200/µl, under ART
Healthy individuals

Detailed Description:
Groups of patients with different immune competencies will be examined. The impact of HIV infection on immune response will be assessed.

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
HIV patients and controls attending specialised clinics, Germany

Inclusion Criteria:

  • HIV-infected individuals
  • controls

Exclusion Criteria:

- none

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Please refer to this study by its ClinicalTrials.gov identifier: NCT00806845

Universität Leipzig
Leipzig, Sachsen, Germany, 04103
Sponsors and Collaborators
Regenerative Medicine Network
University of Leipzig
Study Director: Christian Jassoy, MD Universität Leipzig