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The goal of this study is to examine the impact of iron overload in patients undergoing a bone marrow transplant. We believe that the iron status in these patients is associated with complications for transplant survivors. We will examine the iron status in these patients by MRI and by screening for mutations in genes known to cause iron overload. We will also determine the levels of hepcidin (a hormone produced in the liver that appears to regulate iron homeostasis) from blood and urine.
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Ages Eligible for Study:
5 Years and older (Child, Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Children undergoing allogeneic stem cell transplantation.
Undergoing allogeneic HSCT for malignant or non-malignant conditions
Age greater than or equal to 5 years
Able to undergo MRI without a need for general anesthesia
No metal implants
Signed informed consent (by parent if patient is less than 18 years old, or by patient, if he or she is greater than 18 years old).