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Functional Proteomics of Alveolar Macrophages

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ClinicalTrials.gov Identifier: NCT00806091
Recruitment Status : Completed
First Posted : December 10, 2008
Last Update Posted : December 10, 2008
Sponsor:
Information provided by:

Study Description
Brief Summary:
The purpose of this study is to obtain young white blood cells (monocytes) from the investigators donated blood for research into how these cells change into large, mature white blood cells (macrophages) and how smoking causes Chronic Obstructive Pulmonary Disease (COPD).

Condition or disease
COPD

Detailed Description:
Our research goal is to identify new targets and strategies to help care for patients with Chronic Obstructive Pulmonary Disease (COPD). COPD is a chronic airway inflammatory disorder characterized by a progressive loss of pulmonary function. Mononuclear phagocytes are known to be critically involved in both repair/remodeling and destructive events in COPD. Although smoking is the chief environmental risk factor for COPD, the molecular details responsible for the genesis and progression of smoking-mediated COPD require further investigation. In searching for new knowledge and research strategies for this challenging topic, we have made substantial progress in mononuclear phagocyte proteomics and laid the groundwork for this translational research of COPD.

Study Design

Study Type : Observational
Actual Enrollment : 72 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Functional Proteomics of Alveolar Macrophages
Study Start Date : July 2004
Primary Completion Date : September 2008
Study Completion Date : December 2008
Groups and Cohorts

Group/Cohort
COPD subjects
healthy subjects


Outcome Measures

Primary Outcome Measures :
  1. to define AM's pathogenic pathways underlying the development of COPD [ Time Frame: end of study ]

Secondary Outcome Measures :
  1. to determine protein polymorphism(s) that impact genetic susceptibility to COPD [ Time Frame: end of study ]

Biospecimen Retention:   Samples With DNA
blood BAL fluid breathe condensation saliva

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
smokers with and without COPD, general population
Criteria

Inclusion Criteria:

  • COPD, smoker
  • COPD, non smoker

Exclusion Criteria:

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00806091


Locations
United States, Ohio
The Ohio State University
Columbus, Ohio, United States, 43210
Sponsors and Collaborators
Ohio State University
Investigators
Principal Investigator: Haifeng Wu, MD Ohio State University
More Information

Responsible Party: Haifeng Wu, The Ohio State University
ClinicalTrials.gov Identifier: NCT00806091     History of Changes
Other Study ID Numbers: 2004H0102
First Posted: December 10, 2008    Key Record Dates
Last Update Posted: December 10, 2008
Last Verified: December 2008

Keywords provided by Ohio State University:
AM proteomes will be compared between smokers with and without COPD