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Functional Proteomics of Alveolar Macrophages

This study has been completed.
Information provided by:
Ohio State University Identifier:
First received: December 9, 2008
Last updated: NA
Last verified: December 2008
History: No changes posted
The purpose of this study is to obtain young white blood cells (monocytes) from the investigators donated blood for research into how these cells change into large, mature white blood cells (macrophages) and how smoking causes Chronic Obstructive Pulmonary Disease (COPD).


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Functional Proteomics of Alveolar Macrophages

Further study details as provided by Ohio State University:

Primary Outcome Measures:
  • to define AM's pathogenic pathways underlying the development of COPD [ Time Frame: end of study ]

Secondary Outcome Measures:
  • to determine protein polymorphism(s) that impact genetic susceptibility to COPD [ Time Frame: end of study ]

Biospecimen Retention:   Samples With DNA
blood BAL fluid breathe condensation saliva

Enrollment: 72
Study Start Date: July 2004
Study Completion Date: December 2008
Primary Completion Date: September 2008 (Final data collection date for primary outcome measure)
COPD subjects
healthy subjects

Detailed Description:
Our research goal is to identify new targets and strategies to help care for patients with Chronic Obstructive Pulmonary Disease (COPD). COPD is a chronic airway inflammatory disorder characterized by a progressive loss of pulmonary function. Mononuclear phagocytes are known to be critically involved in both repair/remodeling and destructive events in COPD. Although smoking is the chief environmental risk factor for COPD, the molecular details responsible for the genesis and progression of smoking-mediated COPD require further investigation. In searching for new knowledge and research strategies for this challenging topic, we have made substantial progress in mononuclear phagocyte proteomics and laid the groundwork for this translational research of COPD.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
smokers with and without COPD, general population

Inclusion Criteria:

  • COPD, smoker
  • COPD, non smoker

Exclusion Criteria:

  Contacts and Locations
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Please refer to this study by its identifier: NCT00806091

United States, Ohio
The Ohio State University
Columbus, Ohio, United States, 43210
Sponsors and Collaborators
Ohio State University
Principal Investigator: Haifeng Wu, MD Ohio State University
  More Information

Responsible Party: Haifeng Wu, The Ohio State University Identifier: NCT00806091     History of Changes
Other Study ID Numbers: 2004H0102
Study First Received: December 9, 2008
Last Updated: December 9, 2008

Keywords provided by Ohio State University:
AM proteomes will be compared between smokers with and without COPD processed this record on August 21, 2017