The Effects of High Dose Fish Oil Supplementation on Delayed Onset Muscle Soreness and Inflammatory Markers
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00805870|
Recruitment Status : Completed
First Posted : December 10, 2008
Results First Posted : September 5, 2012
Last Update Posted : September 5, 2012
|Condition or disease||Intervention/treatment||Phase|
|Muscle Damage Muscle Inflammation||Drug: Lovaza (omega-3-acid ethyl esters) Drug: Wheat Germ Oil||Phase 2|
When a person exercises at a high intensity or starts a new exercise program, muscle soreness will develop. Muscle soreness that peaks between 24-72 hours after exercise and diminishes in 5-7 days is characterized as delayed onset muscle soreness (DOMS). DOMS is associated with the eccentric phase of exercise, where the muscle is actively creating force while lengthening. The onset of muscle soreness is part of an inflammatory response due to the muscular damage caused by the exercise.
Research has shown that fish oils have anti-inflammatory properties. Direct intake of various polyunsaturated fatty acids (PUFA) alters the cell membrane fatty acid composition, which, in turn modulates cell/tissue response to infection, injury and inflammatory events. These properties may be beneficial to relieve muscle soreness.
Therefore, the purpose of this study is to determine the effects of fish oil supplementation (Lovaza, GlaxoSmithKline, 3 grams per day for 65 days) on muscle strength, muscle soreness and inflammation following exercise.
Participants will be randomly assigned to one of two groups: Lovaza (3 grams/day) or placebo. Participants will consume either the Lovaza or the placebo for 65 consecutive days. On Day 60, participants will have baseline measurements of muscle strength, muscle soreness, creatine kinase activity, and muscle inflammatory marker assessed. Participants will then perform eccentric exercise on an isokinetic dynamometer using the quadriceps muscles in order to induce muscle soreness. On each of Days 61-65, muscle strength, muscle soreness, creatine kinase activity, and muscle inflammatory markers will again be assessed.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||20 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||The Effects of High Dose Fish Oil Supplementation on Delayed Onset Muscle Soreness and Inflammatory Markers|
|Study Start Date :||March 2009|
|Actual Primary Completion Date :||December 2009|
|Actual Study Completion Date :||February 2010|
Experimental: Fish Oil
Lovaza, 3 grams/day for 65 days
Drug: Lovaza (omega-3-acid ethyl esters)
Lovaza, 3 grams per day for 65 days
Placebo Comparator: Control
Wheat Germ Oil, 3 grams/day for 65 days
Drug: Wheat Germ Oil
Wheat germ oil, 3 grams/day for 65 days
- Quadriceps Muscle Strength [ Time Frame: 6 days ]Quadriceps muscle strength is the maximal amount of force that the quadriceps muscles can produce during isometric knee extension exercise.
- Muscle Soreness of the Quadriceps Using an Algometer Strain Gauge [ Time Frame: 6 days ]The required amount of force applied to the quadriceps to elicit pain or discomfort.
- Creatine Kinase Activity Measured in Blood [ Time Frame: 6 days ]Creatine kinase activity is an indirect indicator of muscle damage.
- Interleukin-6 Measured in Blood [ Time Frame: 6 days ]Interleukin-6 is an indirect indicator of muscle inflammation.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00805870
|United States, Michigan|
|Western Michigan University|
|Kalamazoo, Michigan, United States, 49008|
|Principal Investigator:||Christopher C Cheatham, Ph.D.||Western Michigan University|