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Effect of Exercise on Heart Function in Healthy Elderly People

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ClinicalTrials.gov Identifier: NCT00804518
Recruitment Status : Completed
First Posted : December 9, 2008
Last Update Posted : July 18, 2016
Sponsor:
Information provided by (Responsible Party):
Norwegian University of Science and Technology

Brief Summary:
The purpose of this study is to determine the effect of aerobic interval training on left- and right ventricular diastolic- and systolic function on healthy, sedate people over 70 years. The old sedate cohort will be compared to young, sedate subjects also performing aerobic interval training and old master athletes without intervention.

Condition or disease Intervention/treatment Phase
Diastolic Dysfunction Other: Aerobic interval training Not Applicable

Detailed Description:

Aging is associated with a reduced diastolic and systolic function of the heart. Earlier studies have shown that physical exercise can improve both systolic and diastolic function. However the impact on age-related cardiac function is to some extent conflicting. The use of different training intensities will impact on the cardiac result. We have in earlier studies shown aerobic interval training at 90 % of maximal heart rate (4x4 minutes) to have more impact on cardiac function, endothelial function and maximal oxygen uptake compared to moderate intensity.

To our knowledge the effect of aerobic interval training on cardiac function has not been studied in an old, sedate group before.


Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 45 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Aerobic Interval Training Reduces and Compensates Age Related Decline in Cardiac Function
Study Start Date : November 2008
Actual Primary Completion Date : March 2009
Actual Study Completion Date : August 2009

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arm Intervention/treatment
Experimental: Exercise intervention Other: Aerobic interval training
High intensity aerobic interval training consists of 10 minutes warm up at ~60% of maximal heart rate, 4x4 minutes intervals at 90-95 % of maximal heart rate corresponding to 85-90% of VO2max) walking/running uphill on a treadmill, with three minutes active pause between the exercise bouts at 60-70% maximal heart rate. The session is terminated with 3 minutes cool down. Total exercise time is 38 minutes.The training is supervised by an exercise physiologist and the subjects train 3 times per week for 12 weeks.



Primary Outcome Measures :
  1. Improvement of left and right ventricular early diastolic tissue velocity at rest and sub maximal exercise ,e'. [ Time Frame: 12 weeks ]

Secondary Outcome Measures :
  1. Improvement of left and right ventricular systolic tissue velocity function at rest and sub maximal exercise, S'. [ Time Frame: 12weeks ]


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Ages Eligible for Study:   70 Years and older   (Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • over 70 years, healthy
  • not exercising more than twice per week

Exclusion Criteria:

  • chronic illness
  • chronic use of any medication
  • regular smoking
  • metabolic or cardiovascular diseases

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00804518


Locations
Norway
Ntnu/Dmf/Isb
Trondheim, Sør-Trøndelag, Norway, 7489
Sponsors and Collaborators
Norwegian University of Science and Technology
Investigators
Principal Investigator: Charlotte Bjork Ingul, PhD NTNU

Publications of Results:
Responsible Party: Norwegian University of Science and Technology
ClinicalTrials.gov Identifier: NCT00804518     History of Changes
Other Study ID Numbers: 4.2008.2177
First Posted: December 9, 2008    Key Record Dates
Last Update Posted: July 18, 2016
Last Verified: July 2016

Keywords provided by Norwegian University of Science and Technology:
Aging
Diastolic dysfunction
Systolic function
Exercise
Echocardiography
tissue Doppler imaging
Cardiac function