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Effect of Exercise on Heart Function in Healthy Elderly People

This study has been completed.
Information provided by (Responsible Party):
Norwegian University of Science and Technology Identifier:
First received: December 8, 2008
Last updated: July 15, 2016
Last verified: July 2016
The purpose of this study is to determine the effect of aerobic interval training on left- and right ventricular diastolic- and systolic function on healthy, sedate people over 70 years. The old sedate cohort will be compared to young, sedate subjects also performing aerobic interval training and old master athletes without intervention.

Condition Intervention
Diastolic Dysfunction
Other: Aerobic interval training

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: Aerobic Interval Training Reduces and Compensates Age Related Decline in Cardiac Function

Resource links provided by NLM:

Further study details as provided by Norwegian University of Science and Technology:

Primary Outcome Measures:
  • Improvement of left and right ventricular early diastolic tissue velocity at rest and sub maximal exercise ,e'. [ Time Frame: 12 weeks ]

Secondary Outcome Measures:
  • Improvement of left and right ventricular systolic tissue velocity function at rest and sub maximal exercise, S'. [ Time Frame: 12weeks ]

Enrollment: 45
Study Start Date: November 2008
Study Completion Date: August 2009
Primary Completion Date: March 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Exercise intervention Other: Aerobic interval training
High intensity aerobic interval training consists of 10 minutes warm up at ~60% of maximal heart rate, 4x4 minutes intervals at 90-95 % of maximal heart rate corresponding to 85-90% of VO2max) walking/running uphill on a treadmill, with three minutes active pause between the exercise bouts at 60-70% maximal heart rate. The session is terminated with 3 minutes cool down. Total exercise time is 38 minutes.The training is supervised by an exercise physiologist and the subjects train 3 times per week for 12 weeks.

Detailed Description:

Aging is associated with a reduced diastolic and systolic function of the heart. Earlier studies have shown that physical exercise can improve both systolic and diastolic function. However the impact on age-related cardiac function is to some extent conflicting. The use of different training intensities will impact on the cardiac result. We have in earlier studies shown aerobic interval training at 90 % of maximal heart rate (4x4 minutes) to have more impact on cardiac function, endothelial function and maximal oxygen uptake compared to moderate intensity.

To our knowledge the effect of aerobic interval training on cardiac function has not been studied in an old, sedate group before.


Ages Eligible for Study:   70 Years and older   (Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • over 70 years, healthy
  • not exercising more than twice per week

Exclusion Criteria:

  • chronic illness
  • chronic use of any medication
  • regular smoking
  • metabolic or cardiovascular diseases
  Contacts and Locations
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Please refer to this study by its identifier: NCT00804518

Trondheim, Sør-Trøndelag, Norway, 7489
Sponsors and Collaborators
Norwegian University of Science and Technology
Principal Investigator: Charlotte Bjork Ingul, PhD NTNU
  More Information

Responsible Party: Norwegian University of Science and Technology Identifier: NCT00804518     History of Changes
Other Study ID Numbers: 4.2008.2177
Study First Received: December 8, 2008
Last Updated: July 15, 2016

Keywords provided by Norwegian University of Science and Technology:
Diastolic dysfunction
Systolic function
tissue Doppler imaging
Cardiac function processed this record on May 25, 2017