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Comparison of the Effects of Bevacizumab Before vs After Pattern Panretinal Photocoagulation

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified December 2008 by Asociación para Evitar la Ceguera en México.
Recruitment status was:  Recruiting
Information provided by:
Asociación para Evitar la Ceguera en México Identifier:
First received: December 3, 2008
Last updated: December 5, 2008
Last verified: December 2008
Compare the effect of an intravitreal injection of bevacizumab previous or posterior of panretinal laser photocoagulation (PRLP) with a pattern laser; to prevent and reduce diabetic macular edema (DME) in patients with proliferative diabetic retinopathy (PDR) with DME.

Condition Intervention Phase
Macular Edema
Drug: bevacizumab
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Phase 4 Comparison of the Effects of Bevacizumab Before vs After Pattern Panretinal Photocoagulation

Resource links provided by NLM:

Further study details as provided by Asociación para Evitar la Ceguera en México:

Primary Outcome Measures:
  • Central macular thickness [ Time Frame: baseline, 10 days, 52 days, 85 days ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Best corrected visual acuity [ Time Frame: baseline, 10 days, 52 days, 85 days ] [ Designated as safety issue: No ]

Estimated Enrollment: 15
Study Start Date: July 2008
Estimated Primary Completion Date: July 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Group A
Bevacizumab before panretinal photocoagulation.
Drug: bevacizumab
Intravitreal bevacizumab before panretinal photocoagulation
Experimental: Group B
Bevacizumab after panretinal photocoagulation
Drug: bevacizumab
Intravitreal Bevacizumab after panretinal photocoagulation


Ages Eligible for Study:   40 Years to 70 Years   (Adult, Senior)
Genders Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients with proliferative diabetic retinopathy
  • patients with macular edema

Exclusion Criteria:

  • patients with previous treatments
  • patients with ocular surgeries
  Contacts and Locations
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Please refer to this study by its identifier: NCT00804206

Asociación para Evitar la Ceguera en México
México, Mexico, 04030
Sponsors and Collaborators
Asociación para Evitar la Ceguera en México
  More Information

Responsible Party: Asociación para evitar la ceguera en mexico, APEC Identifier: NCT00804206     History of Changes
Other Study ID Numbers: APEC-040 
Study First Received: December 3, 2008
Last Updated: December 5, 2008
Health Authority: Mexico: Ministry of Health

Keywords provided by Asociación para Evitar la Ceguera en México:
Intravitreal injection of Bevacizumab
Visual acuity
central retinal thickness
color studies, Farnsworth-Munsell
electroretinogram studies

Additional relevant MeSH terms:
Macular Edema
Macular Degeneration
Retinal Degeneration
Retinal Diseases
Eye Diseases
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Physiological Effects of Drugs
Growth Inhibitors
Antineoplastic Agents processed this record on January 17, 2017