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Magnetic Resonance Imaging Follow-up on Temporomandibular Arthritis in Children With Juvenile Idiopathic Arthritis

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified December 2008 by University Hospital Tuebingen.
Recruitment status was:  Recruiting
Information provided by:
University Hospital Tuebingen Identifier:
First received: December 2, 2008
Last updated: NA
Last verified: December 2008
History: No changes posted

Children with juvenile idiopathic arthritis (JIA) suffer in up to 87% of the cases of arthritis of the temporomandibular joints (TMJs). Magnetic resonance imaging (MRI) is the only modality for the early diagnosis of TMJ involvement.

Aim of the study is to compare symptoms and clinical findings with MRI and ultrasonography results and to describe the action of the current medication on the arthritis of the TMJs.

Condition Intervention
Juvenile Idiopathic Arthritis
Procedure: Steroid injection into the TMJs.

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Arthritis of the Temporomandibular Joints in Children With Juvenile Idiopathic Arthritis- Pilot Study on Diagnostic Value of Ultrasonography and Magnetic Resonance Imaging and Influence of Drug Treatment

Resource links provided by NLM:

Further study details as provided by University Hospital Tuebingen:

Primary Outcome Measures:
  • TMJ arthritis on MRI [ Time Frame: every three to six months from recruitment to end of study ]

Secondary Outcome Measures:
  • TMJ arthritis on ultrasound [ Time Frame: every three to six months from recruitment to end of study ]
  • Action of current medication on TMJ arthritis. [ Time Frame: every three to six months from recruitment to end of study ]

Estimated Enrollment: 50
Study Start Date: May 2008
Estimated Study Completion Date: June 2010
Estimated Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Children with JIA Procedure: Steroid injection into the TMJs.
In case of otherwise noncontrollable TMJ involvement steroids are injected into arthritic TMJs under MRI guidance.


Ages Eligible for Study:   7 Years to 17 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Children with JIA.

Inclusion Criteria:

  • Children with defined JIA.

Exclusion Criteria:

  • Children without defined diagnosis of JIA.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00801593

University Children's Hospital
Tuebingen, Baden-Wuerttemberg, Germany, 72076
Sponsors and Collaborators
University Hospital Tuebingen
Principal Investigator: Nikolay Tzaribachev, MD University Hospital Tuebingen
  More Information

Responsible Party: Nikolay Tzaribachev, Dr., University Children's Hospital, Tuebingen Identifier: NCT00801593     History of Changes
Other Study ID Numbers: TMJ PROSPECT2008 
Study First Received: December 2, 2008
Last Updated: December 2, 2008

Keywords provided by University Hospital Tuebingen:

Additional relevant MeSH terms:
Arthritis, Juvenile
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases processed this record on February 20, 2017