Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Derivation of Induced Pluripotent Stem Cells From an Existing Collection of Human Somatic Cells

This study is currently recruiting participants. (see Contacts and Locations)
Verified February 2017 by Benjamin Reubinoff, Hadassah Medical Organization
Information provided by (Responsible Party):
Benjamin Reubinoff, Hadassah Medical Organization Identifier:
First received: December 2, 2008
Last updated: February 28, 2017
Last verified: February 2017

Induced pluripotent stem cells potentially may be useful in the future as an unlimited source of cells for transplantation.

The major goal of the project is to develop human iPS cells from various types of cell cultures or lines from existing collections. The IPS cells will be developed for modeling diseases, for developing the technology that may eventually allow the use of IPS cells for transplantation therapy, and for basic research.

Amyotrophic Lateral Sclerosis

Study Type: Observational
Study Design: Observational Model: Other
Time Perspective: Prospective
Official Title: Derivation of Induced Pluripotent Stem Cells From an Existing Collection of Human Somatic Cells

Resource links provided by NLM:

Further study details as provided by Benjamin Reubinoff, Hadassah Medical Organization:

Estimated Enrollment: 25
Study Start Date: November 2008
Estimated Study Completion Date: December 2020
Estimated Primary Completion Date: December 2020 (Final data collection date for primary outcome measure)
Detailed Description:

The potential to reprogram somatic cells into an embryonic state raises multiple basic research questions related both to the process of reprogramming and the properties of iPS cells. We will use various approaches to study the molecular mechanisms and processes that occur during reprogramming. We will use various experimental systems to characterize and study the properties of the iPS cells, their biology, developmental potential, capability to give rise to functional differentiated progeny etc.

We will induce the differentiation of the iPS cells towards specific cell lineages and the progeny can be used to study the pathogenesis of diseases. They will be used for developing new therapeutic approaches and for high throughput screening of factors for potential toxic or therapeutic effects.

All samples will be non-identified.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
We will use human somatic cells from existing collections.

Inclusion Criteria:

  • Volunteers
  • Male and Female

Exclusion Criteria:

  • Below the official age of consent
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00801333

Contact: Benjamin E. Reubinoff, M.D. PhD. 011-972-2-677-4569

Hadassah Medical Organization - Ein Kerem Campus Recruiting
Jerusalem, Israel, 91120
Contact: Hadas Lemberg, PhD    011-972-2-677-6095   
Sponsors and Collaborators
Hadassah Medical Organization
  More Information

Responsible Party: Benjamin Reubinoff, Professor, Hadassah Medical Organization Identifier: NCT00801333     History of Changes
Other Study ID Numbers: 0511-08-HMO
Study First Received: December 2, 2008
Last Updated: February 28, 2017

Keywords provided by Benjamin Reubinoff, Hadassah Medical Organization:

Additional relevant MeSH terms:
Motor Neuron Disease
Amyotrophic Lateral Sclerosis
Neurodegenerative Diseases
Nervous System Diseases
Neuromuscular Diseases
Spinal Cord Diseases
Central Nervous System Diseases
TDP-43 Proteinopathies
Proteostasis Deficiencies
Metabolic Diseases processed this record on May 25, 2017