Increased Expression of Adiponectin Receptor 2 in the Mononuclear Cells in Children With Prader-Willi Syndrome
|ClinicalTrials.gov Identifier: NCT00800852|
Recruitment Status : Completed
First Posted : December 2, 2008
Last Update Posted : December 2, 2008
The inflammatory process is involved in the pathogenesis of obesity. Prader-Willi syndrome (PWS) is a genetic model of syndromic obesity. Adiponectin is an adipokine with potent anti-inflammatory properties, and its effect is mediated through adiponectin receptors 1 (adipoR1) and 2 (adipoR2).
Objective of this study is to compare the expression of adipoR1, adipoR2, and adiponectin in peripheral blood mononuclear cells (PBMCs) in PWS children and obese control and to correlate receptor expression with insulin sensitivity and obesity-related parameters.
|Condition or disease|
|Obesity Prader-Willi Syndrome|
|Study Type :||Observational|
|Official Title:||Increased Expression of Adiponectin Receptor 2 in the Mononuclear Cells in Children With Prader-Willi Syndrome|
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00800852
|Principal Investigator:||Don-Kyu Jin, M.D.||Samsung Medical Center, Sungkyunkwan Uiversity School of Medicine|