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Exercise Induced Asthma and Airway Reactivity in Athletes

This study has been completed.
Information provided by:
Skane University Hospital Identifier:
First received: November 25, 2008
Last updated: August 2, 2011
Last verified: September 2008
The overall aim is to explore pathophysiological factors related to airway hyperresponsiveness to direct and indirect provocation stimuli in athletes with different sport activities, with special focus on epithelial reaction linked to CC16 and to eicosanoid related inflammatory response. The investigators also wish to compare indirect testing done as hyper osmotic challenge with Mannitol compared to a defined sport specific exercise challenge.

Respiratory Function Tests

Study Type: Observational
Study Design: Time Perspective: Cross-Sectional
Official Title: Explorative Study "Exercise Induced Asthma and Airway Reactivity in Athletes"

Resource links provided by NLM:

Further study details as provided by Skane University Hospital:

Enrollment: 300
Study Start Date: March 2008
Study Completion Date: December 2009
Detailed Description:

By non-invasive tools the investigators wish to characterize type of airway reaction to various provocative stimuli in athletes doing two different sort activities, Tennis or swimming. As controls are being used sedentary age-matched controls from the same region, exposed to the same school environment. Thus we wish to:

  • explore the prevalence of positive mannitol reactivity among swimmers and tennis player and how this relates to symptoms, disease history and to a sport specific exercise provocation test.
  • compare the results from sport specific testing with a standardized eucapnic hyperventilation test (EHV)
  • compare the overall reactivity to mannitol or EHV among swimmers and tennis players compared to aged matched controls.
  • explore the role by CC16 in airway reactivity to different provocative stimuli and to see whether there is a difference between different sport activities, different test protocols and between athletes and controls.
  • explore evidence of eicosanoid related inflammatory reaction in athletes and controls in relation to different provocative stimuli

The study population consists of 100 elite swimmers, 100 elite tennis players and 100 non-elite, eged matched controls. In the latter group, 30 are aged matched non-atopic non-asthmatic controls.


Ages Eligible for Study:   16 Years to 25 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
100 elite swimmers 100 elite tennis players 100 aged matched non-atletic subjects, 30 aged-matcked healthy non-atopic controls

Inclusion Criteria:

  • Subjects aged 16-19 from Skåne.
  • All should approve attendance in the study by signing an informed consent. Igf they are aged under 18, parents should also sign.
  • Three groups are included
  • Elite aspiring swimmers with an average training intensity of at least hours per week the last year.

Exclusion Criteria:

  Contacts and Locations
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Please refer to this study by its identifier: NCT00798564

Sponsors and Collaborators
Skane University Hospital
Principal Investigator: Leif H Bjermer, MD, PhD Lund University
  More Information

Responsible Party: Professor Leif Bjermer, Lung and Alllergy research unit, Heart & Lung division, Lund University Hospital Identifier: NCT00798564     History of Changes
Other Study ID Numbers: 34797
Study First Received: November 25, 2008
Last Updated: August 2, 2011

Keywords provided by Skane University Hospital:

Additional relevant MeSH terms:
Asthma, Exercise-Induced
Bronchial Diseases
Respiratory Tract Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Immune System Diseases processed this record on September 19, 2017