Exercise Induced Asthma and Airway Reactivity in Athletes

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00798564
Recruitment Status : Completed
First Posted : November 26, 2008
Last Update Posted : August 4, 2011
Information provided by:
Skane University Hospital

Brief Summary:
The overall aim is to explore pathophysiological factors related to airway hyperresponsiveness to direct and indirect provocation stimuli in athletes with different sport activities, with special focus on epithelial reaction linked to CC16 and to eicosanoid related inflammatory response. The investigators also wish to compare indirect testing done as hyper osmotic challenge with Mannitol compared to a defined sport specific exercise challenge.

Condition or disease
Respiratory Function Tests

Detailed Description:

By non-invasive tools the investigators wish to characterize type of airway reaction to various provocative stimuli in athletes doing two different sort activities, Tennis or swimming. As controls are being used sedentary age-matched controls from the same region, exposed to the same school environment. Thus we wish to:

  • explore the prevalence of positive mannitol reactivity among swimmers and tennis player and how this relates to symptoms, disease history and to a sport specific exercise provocation test.
  • compare the results from sport specific testing with a standardized eucapnic hyperventilation test (EHV)
  • compare the overall reactivity to mannitol or EHV among swimmers and tennis players compared to aged matched controls.
  • explore the role by CC16 in airway reactivity to different provocative stimuli and to see whether there is a difference between different sport activities, different test protocols and between athletes and controls.
  • explore evidence of eicosanoid related inflammatory reaction in athletes and controls in relation to different provocative stimuli

The study population consists of 100 elite swimmers, 100 elite tennis players and 100 non-elite, eged matched controls. In the latter group, 30 are aged matched non-atopic non-asthmatic controls.

Study Type : Observational
Actual Enrollment : 300 participants
Time Perspective: Cross-Sectional
Official Title: Explorative Study "Exercise Induced Asthma and Airway Reactivity in Athletes"
Study Start Date : March 2008
Actual Study Completion Date : December 2009

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Information from the National Library of Medicine

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Ages Eligible for Study:   16 Years to 25 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
100 elite swimmers 100 elite tennis players 100 aged matched non-atletic subjects, 30 aged-matcked healthy non-atopic controls

Inclusion Criteria:

  • Subjects aged 16-19 from Skåne.
  • All should approve attendance in the study by signing an informed consent. Igf they are aged under 18, parents should also sign.
  • Three groups are included
  • Elite aspiring swimmers with an average training intensity of at least hours per week the last year.

Exclusion Criteria:

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00798564

Sponsors and Collaborators
Skane University Hospital
Principal Investigator: Leif H Bjermer, MD, PhD Lund University

Responsible Party: Professor Leif Bjermer, Lung and Alllergy research unit, Heart & Lung division, Lund University Hospital Identifier: NCT00798564     History of Changes
Other Study ID Numbers: 34797
First Posted: November 26, 2008    Key Record Dates
Last Update Posted: August 4, 2011
Last Verified: September 2008

Keywords provided by Skane University Hospital:

Additional relevant MeSH terms:
Asthma, Exercise-Induced
Bronchial Diseases
Respiratory Tract Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Immune System Diseases