Outcomes of Mechanically Ventilated Patients With Low Serum Testosterone
This is a study to determine the testosterone serum levels in male patient with acute respiratory failure requiring mechanical ventilation. The objective is to determine if low levels exist in this population and if it correlates with length of mechanical ventilation.
Hypothesis: Serum testosterone levels in mechanically ventilated male patients are significantly decreased from normal levels and correlate with disease severity and outcomes.
Acute Respiratory Failure
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Outcomes of Mechanically Ventilated Patients With Low Serum Testosterone|
- Serum testosterone level [ Time Frame: Day 1, 3 and 7 ] [ Designated as safety issue: No ]
- Length of mechanical ventilation [ Time Frame: Days ] [ Designated as safety issue: No ]
|Study Start Date:||December 2008|
|Study Completion Date:||August 2010|
|Primary Completion Date:||August 2010 (Final data collection date for primary outcome measure)|
All male patients with acute respiratory failure requiring mechanical ventilation
- To confirm and quantify the presence of hypotestosteronemia in critically ill male patients with acute respiratory failure requiring mechanical ventilation via endotracheal intubation.
- To correlate serum testosterone levels with disease severity, short-term outcomes, and survival in mechanically ventilated male patients.
- To determine if demographic patient characteristics, such as age, admitting diagnosis, or the presence of co-morbidities, affect serum testosterone levels during mechanical ventilation.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00797433
|United States, Texas|
|University of Texas Health Science Center at Houston|
|Houston, Texas, United States, 77030|
|Principal Investigator:||Khalid F Almoosa, MD||University of Texas|