Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Biological and Cognitive Markers of Violent Behavior in Forensic Patients With Polysubstance Use: Retrospective Evaluation

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified November 2008 by BeerYaakov Mental Health Center.
Recruitment status was:  Active, not recruiting
Information provided by:
BeerYaakov Mental Health Center Identifier:
First received: November 23, 2008
Last updated: November 24, 2008
Last verified: November 2008

Aggressive behavior, both in the form of violence toward others (injury-inflicting or homicide) or toward oneself (suicide or self-injures) create problems of patient management, treatment and paroles.

Biological causes of violent crime were hypothesized by Eysenck (1978), who believed that criminality resulted from a nervous system distinct from that of most people.

The prefrontal cortex, regulates planning of motor acts and executive functions, which are critical for inhibitory ability and control of impulsive outburst were found to be impaired in violent subjects (Hoaken et al, 2003; Blair, 2001; Brower and Price, 2001; Filley et al, 2001; Raine et al, 2000; George et al, 2004; Dolan and Park, 2002; Stevens et al, 2003; Raine and Yang, 2006), especially in impulsive offenders murderers (Raine et al, 1997; 1998). Violence act influenced by nonplaning outboards definite as impulsive aggression (Linnoila and Charney, 1999), which one of the most important factor influenced by dangerous behavior in general (for review: Skodol, 1998, Moeller et al, 2001; Pontius, 2000; 2004; Siever, 2008).

Cholesterol and fats have many roles and may influence brain function and behavior through modification of membranes; myelin; enzyme function; absorption and transport of fat-soluble vitamins and toxins; and steroid hormones and through effects on production, reuptake, or metabolism of neurotransmitters (Boston et al, 1996).

Since 80-th a strong association was found between low cholesterol levels and violent behavior, an association that was not due to age, race, sex, or diagnosis (Mufti et al, 1998; New et al, 1999; Alvarez et al, 2000; Golomb et al, 2000; Hillbrand et al, 2000; Troisi and D'Argenio, 2006; Chakrabarat and Sinha, 2006).

Associations between violent behavior, cognitive functioning and total cholesterol level were contradicted with difference in samples and behavioral parameters: homicide, homicide attempts, rape, physical or verbal aggression, complete suicide or suicide attempts, only partially accounted for each measure of behaviors, suggesting that further investigation is warranted. Because of the inconsistencies in the available data, we studied retrospectively a group of criminal offenders with alcohol and drug use. Our analysis of lipid constituents in serum focused on TC, HDL, LDL, and TG.

Significance of the study. It is possible that cholesterol profile is a biomarker and potential predictor of violent in patients with polydrug use.

The purpose of this retrospective study is to investigate the correlations between cholesterol and cognitive profiles in psychiatric patients with violent behaviour. The demographic and criminal records, clinical characteristics, cholesterol profiles, and cognitive performance data of these patients will be will be intercorrelated.

Condition Intervention
Violent Behavior
Polydrug Use
Alcohol Abuse
Other: chart review

Study Type: Observational
Study Design: Time Perspective: Retrospective

Further study details as provided by BeerYaakov Mental Health Center:

Primary Outcome Measures:
  • The purpose of this retrospective study is to investigate the correlations between cholesterol and cognitive profiles in psychiatric patients with violent behaviour. [ Time Frame: 2008-2009 ]

Estimated Enrollment: 200
Study Start Date: July 2008
Groups/Cohorts Assigned Interventions
adult men with alcohol and polydrug use according to DSM-IV criteria, hospitalized in maximum security department between 2002 - 2008
Other: chart review
  • cholesterol
  • cognitive profiles
  • violent behavior


Ages Eligible for Study:   19 Years to 65 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Age between 19-65 years; men with verified diagnoses of alcohol and polydrug use according to DSM-IV criteria; hospitalized in maximum security department between 2002 - 2008.

Inclusion Criteria:

  1. Age between 19-65 years
  2. Men with verified diagnoses of alcohol and polydrug use according to DSM-IV criteria, underwent cholesterol and cognitive assessment, while being incarcerated in maximum-security forensic facility

Exclusion Criteria:

  1. Subjects suffering from any clinically significant metabolic disorder (e.g. diabetes, hypo-hyperthiorioidosis, et ctr)
  2. Subjects suffering from clinically significant infectional disorder (e.g. tuberculosis, pneumonia, AIDS, active HCV et ctr)
  3. Subjects starving or suffering from severe hepatic or kidney dysfunction and insufficiency
  4. patients with comorbid diagnoses of schizophrenia, schizoaffective disorder and bipolar mood disorder
  5. patients with comorbide mild mental retardation or epilepsy
  6. patients with using cholesterol lowering agent
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00797329

Beer-Yaacov MHC
Beer Yaacov, Israel, 70350
BeerYaakov MHC
Beer Yaakov, Israel, 70350
Sponsors and Collaborators
BeerYaakov Mental Health Center
  More Information

Responsible Party: Dr. Kertzman, BeerYaakov Mental Health Center Identifier: NCT00797329     History of Changes
Other Study ID Numbers: 222CTIL
Study First Received: November 23, 2008
Last Updated: November 24, 2008

Keywords provided by BeerYaakov Mental Health Center:
psychiatric patients with violent behavior

Additional relevant MeSH terms:
Alcohol-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders processed this record on April 28, 2017