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Imaging of Soft Tissues

This study has been completed.
Information provided by (Responsible Party):
Yoav Morag, MD, University of Michigan Identifier:
First received: November 21, 2008
Last updated: November 8, 2016
Last verified: November 2016

The purpose of this study is to evaluate the potential importance of tissue elasticity in the assessment of soft tissues including muscles, tendons and ligaments and other soft tissue structures.

The evaluation of tissue elasticity (easily stretched or moveable) may assist in assessment of various soft tissue structures, such as fatty atrophy of muscles, tendon/ligamentous injury and healing and other soft tissue structures.

Condition Intervention
Soft Tissue Injury
Other: Ultrasound examination

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Elasticity Imaging of Soft Tissues

Further study details as provided by University of Michigan:

Primary Outcome Measures:
  • To assess the potential importance of Sonoelastography in evaluating tissue injury or abnormalities of soft tissues. [ Time Frame: hours ]

Enrollment: 30
Study Start Date: December 2008
Study Completion Date: February 2009
Primary Completion Date: February 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Evaluation of tissue elasticity
Evaluate the potential importance of tissue elasticity in the assessment soft tissue structures.
Other: Ultrasound examination
Sonoelastrography is an ultrasound examination that can determine the elasticity of soft tissue. This examination takes approximately 10 minutes to complete.

Detailed Description:

This is a prospective study that will recruit males and females 18 years of age and older who present to the department for a clinically indicated ultrasound of a superficial soft tissue abnormality with prior or following MRI / CT assessment ordered for clinical purposes.

The elasticity properties of tissues depend on their molecular building blocks and on the organization of these blocks. Injuries, disease etc are known to be associated with changes in tissue elasticity. Little research has been done on the potential of sonoelastographic (elasticity ultrasound imaging) assessment of normal, injured or healing muscles, tendons or ligaments.

Elasticity changes in muscle, ligaments and tendons following injury may have implication on the choice of treatment and help in determine how the length of time needed to heal from an injury.

Stiffness/elasticity of the tissue can be assessed by mechanical excitation with measurement of resultant tissue motion. Reconstruction of the elastic deformability (strain imaging) in real time ultrasound is known as sonoelastography.

Elasticity ultrasound imaging will be performed on the area being evaluated clinically.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Males and non pregnant females with soft tissue abnormalities.

Inclusion Criteria:

  • Subjects who present for a clinically ordered ultrasound for evaluation of a soft tissue abnormality.

Exclusion Criteria:

  • Women who are pregnant
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00796094

United States, Michigan
University of Michigan Hospital
Ann Arbor, Michigan, United States, 48109
Sponsors and Collaborators
University of Michigan
Principal Investigator: Yoav Morag, M.D. University of Michigan
  More Information

Responsible Party: Yoav Morag, MD, Associate Professor of Radiology, University of Michigan Identifier: NCT00796094     History of Changes
Other Study ID Numbers: HUM 20943
Study First Received: November 21, 2008
Last Updated: November 8, 2016
Individual Participant Data  
Plan to Share IPD: Undecided

Additional relevant MeSH terms:
Soft Tissue Injuries
Wounds and Injuries processed this record on April 25, 2017