Relation of Circulating Endothelium-derived Microparticle to Carotid Atherosclerosis

This study has been completed.
Information provided by (Responsible Party):
Hisashi Kai, Kurume University Identifier:
First received: November 20, 2008
Last updated: March 30, 2015
Last verified: March 2015
The investigators hypothesized that circulating endothelium-derived microparticle (EMP) may be a useful surrogate marker of atherosclerosis and future episode of cerebrovascular events. Peripheral blood is drawn at the time of carotid ultrasound examination. Circulating EMPs are counted using flow-cytometry. The correlation among circulating EMP, ultrasound findings, and atherosclerotic risk factors are determined by multiple stepwise regression analysis. The prevalence of cerebrovascular events is also determined during 3-year follow-up period.


Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Relation of Circulating Endothelium-derived Microparticle to Carotid Atherosclerosis

Resource links provided by NLM:

Further study details as provided by Kurume University:

Primary Outcome Measures:
  • The number of circulating EMPs [ Time Frame: at the time of carotid ultrasound examination ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • The occurrence of cerebrovascular and/or cardiovascular events [ Time Frame: 3 years ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA
platelet-poor plasma whole blood urine

Enrollment: 154
Study Start Date: November 2008
Study Completion Date: November 2013
Primary Completion Date: November 2010 (Final data collection date for primary outcome measure)
Carotid atherosclerosis group
Patients who undergo carotid ultrasound examination for carotid atherosclerosis screening


Ages Eligible for Study:   20 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients who undergo carotid ultrasound examination for screening of atheroscrelosis

Inclusion Criteria:

  • Patients who undergo carotid ultrasound examination for screening of atherosclerosis

Exclusion Criteria:

  • Cerebrovascular events within the last 12 months
  • Acute coronary syndrome, coronary and peripheral intervention within the last 6 months
  • Uncontrolled heart failure
  • Other severe systemic diseases
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Please refer to this study by its identifier: NCT00795067

Kurume University Hospital
Kurume, Fukuoka, Japan, 830-0011
Sponsors and Collaborators
Kurume University
Study Chair: Tsutomu Imaizumi, MD, PhD Kurume University
  More Information

Responsible Party: Hisashi Kai, Associate professor of Medicine, Kurume University Identifier: NCT00795067     History of Changes
Other Study ID Numbers: KurumeU-08060 
Study First Received: November 20, 2008
Last Updated: March 30, 2015
Health Authority: Japan: Ministry of Health, Labor and Welfare

Additional relevant MeSH terms:
Carotid Artery Diseases
Arterial Occlusive Diseases
Brain Diseases
Cardiovascular Diseases
Central Nervous System Diseases
Cerebrovascular Disorders
Nervous System Diseases
Vascular Diseases processed this record on May 23, 2016