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Evaluation of Power Doppler US Technique for the Diagnosis of Spondylarthropathy (EchoSpA)

This study has been completed.
Groupe Français d'Etude Génétique des Spondylarthropathies
French Society of Rheumatology
Information provided by (Responsible Party):
Dr Maria-Atonietta D'AGOSTINO, Groupe Français d'Etude Génétique des Spondylarthropathies Identifier:
First received: November 19, 2008
Last updated: October 28, 2016
Last verified: November 2008
The purpose of this study is to evaluate the interest of enthesis sonography for the diagnosis of spondylarthritis, in patients with uncertain diagnosis consulting for clinical symptoms suggestive of spondylarthritis

Ankylosing Spondyloarthitis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Evaluation of Power Doppler US Technique for the Diagnosis of Spondylarthropathy in Patients With Uncertain Diagnosis Consulting for Clinical Symptoms Suggestive of Spondylarthropathy

Resource links provided by NLM:

Further study details as provided by Dr Maria-Atonietta D'AGOSTINO, Groupe Français d'Etude Génétique des Spondylarthropathies:

Biospecimen Retention:   Samples With DNA
whole blood

Enrollment: 489
Study Start Date: December 2004
Study Completion Date: December 2010
Primary Completion Date: March 2010 (Final data collection date for primary outcome measure)
Detailed Description:
Spondylarthritis (SPA) are the second most frequent inflammatory rheumatic disorders and, because it starts early in life and has a chronic progressive course, the impact of this disease on health resources and patient's life quality can be important. Because the characteritic signs of SPA, like radiological evidence of sacro-iliitis, appear late in time, the lag time between the onset first signs of SPA for the patient and the confirmed diagnosis can be very long (up to 8 years). Previous studies proved that patients who are affected by SPA are showing abnormal vascularization of peripheral enthesis more frequently than patients affected by other rheumatic diseases. Ultrasonography in B mode combined with power Doppler (PDUS) is a non invasive and highly sensitive toll which can detect enthesitis and abnormal vsacularization even for the patients who are not showing yet the evidence of SPA's symptomatology. Using PDUS as a early diagnosis tool could lead to the improvement of diagnostic procedures and therapeutic management of SpA and reduce the cost of diagnosis for patient and health insurances.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with a symptomatology which can lead to a SPA diagnosis but with no confirmed diagnosis yet for any rheumatic didease.

Inclusion Criteria:

  • patients < 50 years old, consulting for spinal inflammatory symptoms > 3 months duration
  • patients consulting for arthritis or tenderness joints > 3 months duration
  • patients < 50 years old consulting for enthesitis or dactylitis > 3 months duration
  • patients with uveitis and HLA-B27 positivity
  • relatives of SpA patients consulting for symptoms suggestive of SpA

Exclusion Criteria:

  • patient with confirmed diagnosis of rheumatic disease (included SpA)
  • patient protected by law (patient <18 years old, pregnant woman)
  • patient who can't atempt the RMI
  • patient who will have difficulties to complete the two years of follow-up
  Contacts and Locations
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Please refer to this study by its identifier: NCT00794404

Ambroise Paré Hospital
Boulogne Billancourt, France, 92100
Cavale Blanche Hospital
Brest, France, 29200
Cote de Nacre Hospital
Caen, France, 14033
South Hospital of Grenoble
Echirolles, France, 38434
Conception Hospital
Marseille, France, 13005
Nancy Brabois Hospital
VANDOEUVRE les NANCY, France, 54511
Sponsors and Collaborators
Dr Maria-Atonietta D'AGOSTINO
Groupe Français d'Etude Génétique des Spondylarthropathies
French Society of Rheumatology
Principal Investigator: D'AGOSTINO Maria-Antonietta, MCUPH Ambroise Paré Hospital
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Dr Maria-Atonietta D'AGOSTINO, PU-PH, Groupe Français d'Etude Génétique des Spondylarthropathies Identifier: NCT00794404     History of Changes
Other Study ID Numbers: GESPA
Study First Received: November 19, 2008
Last Updated: October 28, 2016
Individual Participant Data  
Plan to Share IPD: No

Additional relevant MeSH terms:
Spinal Diseases
Bone Diseases
Musculoskeletal Diseases
Joint Diseases processed this record on May 25, 2017