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Performance of CAST (Cellular Antigen Stimulation Test) in Patients With Wasp Venom Allergy: Evaluation of Neutralizing IgG Subclasses

The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2010 by University of Zurich.
Recruitment status was  Active, not recruiting
Information provided by:
University of Zurich Identifier:
First received: November 19, 2008
Last updated: January 19, 2010
Last verified: January 2010

To determine which subclass of IgG in the serum of patients undergoing SIT against wasp venom is able to neutralize the allergen, and therefore to prevent a positive CAST

Condition Intervention
Wasp Venom Allergic Patients
Other: Taking blood samples

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Performance of CAST (Cellular Antigen Stiumulation Test)in Patients With Wasp Venom Allergy. Evaluation of Neutralizing IgG Subclasses

Further study details as provided by University of Zurich:

Biospecimen Retention:   Samples Without DNA

Blood samples

Estimated Enrollment: 20
Study Start Date: January 2009
Estimated Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Hymenoptera allergic patients before allergen specific immunotherapy
Other: Taking blood samples
No intervention is done. Only blood samples are taken.
Hymenoptera allergic patients after allergen specific immunotherapy
Other: Taking blood samples
No intervention is done. Only blood samples are taken.


Ages Eligible for Study:   18 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Wasp venom allergic patients grade III and IV according to H.L. Müller in the age group of 18-75 years


Inclusion criteria:

  • male and female patient with allergy to wasp venom grade III and IV according to H.L. Müller
  • 18-75 years
  • planned SIT against wasp venom or finished 5 years SIT against wsp venom (10/10)

Exclusion criteria:

  • oral corticosteroids
  • chromogycin
  • ketotifen
  • immunosuppressive drugs within the last 2 years
  Contacts and Locations
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Please refer to this study by its identifier: NCT00794287

Zurich, Switzerland
Sponsors and Collaborators
University of Zurich
Study Director: 01 Studienregister MasterAdmins UniversitaetsSpital Zuerich
  More Information

No publications provided

Responsible Party: PD Dr. Thomas Kündig, University of Zurich Identifier: NCT00794287     History of Changes
Other Study ID Numbers: ZU-AgNT-004
Study First Received: November 19, 2008
Last Updated: January 19, 2010
Health Authority: Switzerland: UZurich processed this record on February 27, 2015