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Performance of CAST (Cellular Antigen Stimulation Test) in Patients With Wasp Venom Allergy: Evaluation of Neutralizing IgG Subclasses

This study has been withdrawn prior to enrollment.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00794287
First Posted: November 20, 2008
Last Update Posted: June 4, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University of Zurich
  Purpose
To determine which subclass of IgG in the serum of patients undergoing SIT against wasp venom is able to neutralize the allergen, and therefore to prevent a positive CAST

Condition Intervention
Wasp Venom Allergic Patients Other: Taking blood samples

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Performance of CAST (Cellular Antigen Stiumulation Test)in Patients With Wasp Venom Allergy. Evaluation of Neutralizing IgG Subclasses

Further study details as provided by University of Zurich:

Biospecimen Retention:   Samples Without DNA
Blood samples

Enrollment: 0
Study Start Date: January 2009
Estimated Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
1
Hymenoptera allergic patients before allergen specific immunotherapy
Other: Taking blood samples
No intervention is done. Only blood samples are taken.
2
Hymenoptera allergic patients after allergen specific immunotherapy
Other: Taking blood samples
No intervention is done. Only blood samples are taken.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Wasp venom allergic patients grade III and IV according to H.L. Müller in the age group of 18-75 years
Criteria

Inclusion criteria:

  • male and female patient with allergy to wasp venom grade III and IV according to H.L. Müller
  • 18-75 years
  • planned SIT against wasp venom or finished 5 years SIT against wsp venom (10/10)

Exclusion criteria:

  • oral corticosteroids
  • chromogycin
  • ketotifen
  • immunosuppressive drugs within the last 2 years
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00794287


Locations
Switzerland
Zurich, Switzerland
Sponsors and Collaborators
University of Zurich
Investigators
Study Director: 01 Studienregister MasterAdmins UniversitaetsSpital Zuerich
  More Information

Responsible Party: PD Dr. Thomas Kündig, University of Zurich
ClinicalTrials.gov Identifier: NCT00794287     History of Changes
Other Study ID Numbers: ZU-AgNT-004
First Submitted: November 19, 2008
First Posted: November 20, 2008
Last Update Posted: June 4, 2015
Last Verified: June 2015