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Arterial Blood Pressure-complexity in Septic Patients

This study has suspended participant recruitment.
(Awaiting decision on financial support by Deutsche Forschungsgemeinschaft (DFG))
Information provided by:
University Hospital, Bonn Identifier:
First received: November 17, 2008
Last updated: February 28, 2011
Last verified: January 2011

Arterial blood pressure (ABP) is regulated by multiple, interconnected feedback loops resulting in a variable and complex time course. According to the "decomplexification theory of illness", disease is characterised by a loss or impaired function of feedback loops resulting in a decreased complexity of the ABP-time course and an impaired adaptability of the cardiovascular system.

Decomplexification of physiologic parameters has been shown to occur in coronary heart disease, Parkinson's and Hodgkin's disease, and in subarachnoid hemorrhage, but has not been evaluated in sepsis.

This study is intended to test the hypothesis that complexity of ABP

  • is lower in cardiac surgery versus non-cardiac surgery septic patients,
  • decreases as severity of sepsis increases to severe sepsis and septic shock,
  • is associated with outcome three month after sepsis.


Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Investigation of Arterial Blood Pressure-complexity and Its Relation to Outcome in Comparison Between Cardiac Surgery Versus Non-cardiac Surgery Septic Patients

Resource links provided by NLM:

Further study details as provided by University Hospital, Bonn:

Primary Outcome Measures:
  • short form-36 [ Time Frame: 3 month after discharge ]

Estimated Enrollment: 72
Study Start Date: January 2009
Estimated Study Completion Date: December 2012
Estimated Primary Completion Date: December 2012 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
patients treated at the Intensive Care Unit of a University Hospital

Inclusion Criteria:

  • patients suffering from sepsis, severe sepsis or septic shock

Exclusion Criteria:

  • pregnancy
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Please refer to this study by its identifier: NCT00793078

Dept. of Anaesthesiology and Intensive Care Medicine, University of Bonn
Bonn, Germany, 53105
Sponsors and Collaborators
University Hospital, Bonn
Principal Investigator: Martin Soehle, M.D., D.E.S.A., D. habil. Dept. of Anaesthesiology and Intensive Care Medicine, University of Bonn
  More Information

Responsible Party: Priv.-Doz. Dr. med. Martin Soehle, D.E.S.A., Dept. of Anaesthesiology and Intensive Care Medicine, University of Bonn Identifier: NCT00793078     History of Changes
Other Study ID Numbers: VCS2009
Study First Received: November 17, 2008
Last Updated: February 28, 2011

Keywords provided by University Hospital, Bonn:
arterial blood pressure

Additional relevant MeSH terms:
Systemic Inflammatory Response Syndrome
Pathologic Processes processed this record on April 28, 2017