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Effect of Cognitive Behavioral Therapy in OCD Highlighted by Neuropsychological Tests and MRI: Pathophysiology and Treatment Outcome Predictors

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ClinicalTrials.gov Identifier: NCT00792038
Recruitment Status : Completed
First Posted : November 17, 2008
Last Update Posted : August 2, 2012
Sponsor:
Information provided by (Responsible Party):
University of Aarhus

Brief Summary:
OCD patients are assessed before and after treatment using diagnostic tools, rating scales neuropsychological assessment and functional and structural MR-scans.

Condition or disease
Obsessive-Compulsive Disorder

Study Type : Observational
Actual Enrollment : 88 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Effect of Cognitive Behavioral Therapy in OCD Highlighted by Neuropsychological Tests and MRI: Pathophysiology and Treatment Outcome Predictors
Study Start Date : January 2009
Actual Primary Completion Date : July 2012
Actual Study Completion Date : July 2012

Group/Cohort
1
OCD patients
2
Normal Controls



Primary Outcome Measures :
  1. Y-Bocs [ Time Frame: Before and after treatment approx 20 weeks apart ]

Biospecimen Retention:   Samples With DNA
Full blood


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Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
OCD patients from the primary care clinics in middle Jutland, Denmark
Criteria

Inclusion Criteria:

1. Steady state medication 3 months prior to the study

Exclusion Criteria:

  1. History of head trauma or other organic brain disease
  2. Pregnancy.
  3. Pacemaker or other ferromagnetic materials in the body.
  4. Comorbid psychiatric illnesses assessed using SCAN- interview (30) other than moderate depression (Ham-D<17) or anxiety disorders.
  5. Antipsychotics

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00792038


Locations
Denmark
Aarhus University Hospital, Risskov
Risskov, Denmark, 8240
Sponsors and Collaborators
University of Aarhus
Investigators
Principal Investigator: Tue BH Hartmann Aarhus University Hospital, Risskov
Study Director: Sanne Kjær Aarhus University Hospital, Risskov

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: University of Aarhus
ClinicalTrials.gov Identifier: NCT00792038     History of Changes
Other Study ID Numbers: M-20080161
First Posted: November 17, 2008    Key Record Dates
Last Update Posted: August 2, 2012
Last Verified: August 2012

Keywords provided by University of Aarhus:
Psychological tests
Magnetic Resonance Imaging
Cognitive therapy

Additional relevant MeSH terms:
Compulsive Personality Disorder
Obsessive-Compulsive Disorder
Personality Disorders
Mental Disorders
Anxiety Disorders