Loaded Breathing Training in Essential Hypertension
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ClinicalTrials.gov Identifier: NCT00791986 |
Recruitment Status :
Terminated
(End of study time and budget permission)
First Posted : November 17, 2008
Last Update Posted : March 7, 2018
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Condition or disease | Intervention/treatment | Phase |
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Essential Hypertension | Device: ULB , LB | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 30 participants |
Allocation: | Randomized |
Intervention Model: | Factorial Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Supportive Care |
Official Title: | Effects of Loaded Breathing Training on Blood Pressure in Essential Hypertensive Patients |
Study Start Date : | May 2006 |
Actual Primary Completion Date : | December 2007 |
Actual Study Completion Date : | December 2008 |

Arm | Intervention/treatment |
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No Intervention: control
The patients in this control group do not conduct any breathing training.
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Experimental: ULB
The patients conduct controlled slow breathing training using the WPTB device without inspiratory resistance.
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Device: ULB , LB
ULB: The patients breath in slowly without resistance via the water pressure threshold breathing (WPTB) device, 30 min/day, 7 days/week for 8 weeks. LB : The patients breath in slowly against resistance of 20 cmH2O provided by the water pressure threshold breathing (WPTB) device, 30 min/day, 7 days/week for 8 weeks. Other Names:
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Experimental: LB
The patients breath in against resistance using WPTB device.
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Device: ULB , LB
ULB: The patients breath in slowly without resistance via the water pressure threshold breathing (WPTB) device, 30 min/day, 7 days/week for 8 weeks. LB : The patients breath in slowly against resistance of 20 cmH2O provided by the water pressure threshold breathing (WPTB) device, 30 min/day, 7 days/week for 8 weeks. Other Names:
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- Home blood pressure [ Time Frame: Pre- and post - 8 weeks of intervention at rest ]
- Office blood pressure [ Time Frame: Pre- and post- 8 weeks of intervention at rest ]
- Exercising blood pressure [ Time Frame: Blood pressure during exercise at pre- and post-8 weeks of intervention ]
- Heart rate variability [ Time Frame: Heart rate variability at pre-and post- 8 weeks of intervention ]

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Ages Eligible for Study: | 35 Years to 65 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Clinical diagnosis of essential hypertension stage I-II
Exclusion Criteria:
- Respiratory disease
- Diabetes mellitus
- Heart disease
- Renal disease
- Cerebrovascular disease
- Dyslipidemia
- Pregnancy

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00791986
Thailand | |
Cardiopulmonary Physical Therapy Research Room, Faculty of Asociated Medical Sciences, Khon Kaen University. | |
Khon Kaen, Thailand, 40002 |
Study Chair: | Chulee U Jones, Ph.D. | Department of Physical Therapy, Faculty of Associated Medical Sciences, Khon Kaen University. | |
Principal Investigator: | Benjarat Sangthong, M.Sc. | Faculty of Physical Therapy, Rungsit University |
Responsible Party: | Benjarat Sangthong, Faculty of associated medical science, Khon Kaen University |
ClinicalTrials.gov Identifier: | NCT00791986 |
Other Study ID Numbers: |
KKU-475090015-0 |
First Posted: | November 17, 2008 Key Record Dates |
Last Update Posted: | March 7, 2018 |
Last Verified: | March 2018 |
Breathing exercise blood pressure hypertension |
Respiratory Aspiration Hypertension Essential Hypertension Vascular Diseases |
Cardiovascular Diseases Respiration Disorders Respiratory Tract Diseases Pathologic Processes |