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Mechanisms of Fronto-Subcortical Dysfunction: Comparing PD and OCD

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified November 2008 by Sheba Medical Center.
Recruitment status was:  Not yet recruiting
University of Haifa
Israel Science Foundation
Information provided by:
Sheba Medical Center Identifier:
First received: November 12, 2008
Last updated: NA
Last verified: November 2008
History: No changes posted
The purpose of this study is to characterize and compare irregularities in dopaminergic function in fronto-subcortical circuits, between Parkinson's Disease patients (ON and OFF medication) and patients with obsessive-compulsive disorder, by examining performance on cognitive tasks involving cognitive flexibility, decision-making, and attentional bias.

Parkinson's Disease Obsessive-Compulsive Disorder

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Characterizing Mechanisms of Fronto-Subcortical Dysfunction: A Comparison Between Parkinson's Disease and Obsessive-Compulsive Disorder

Resource links provided by NLM:

Further study details as provided by Sheba Medical Center:

Estimated Enrollment: 100
Study Start Date: December 2008
Estimated Study Completion Date: December 2011
Estimated Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
Parkinson's Disease
Patients with idiopathic Parkinson's disease
Obsessive-compulsive disorder
Individuals with a diagnosis of obsessive-compulsive disorder
OCD controls
Healthy controls, matched in age and number to obsessive-compulsive group
PD controls
Healthy controls, matched in age and number to Parkinson's disease group


Ages Eligible for Study:   16 Years to 85 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
private and hospital-based clinics, healthy volunteers

Inclusion Criteria:

  • idiopathic PD or
  • OCD
  • for control group - age-matched to study groups

Exclusion Criteria:

  • psychotic symptoms (past or present)
  • head injury with loss of consciousness
  • other neurological conditions (excepting PD in PD group)
  • for OCD group - use of dopaminergic medications
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00790634

Contact: Sharon Hassin, MD 97235305791
Contact: Sari Meril, M.Sc 972

Sponsors and Collaborators
Sheba Medical Center
University of Haifa
Israel Science Foundation
  More Information

Responsible Party: Dr. Sharon Hassin, principal investigator, Sheba Medical Center Identifier: NCT00790634     History of Changes
Other Study ID Numbers: SHEBA-08-5473-SH-CTIL
Study First Received: November 12, 2008
Last Updated: November 12, 2008

Additional relevant MeSH terms:
Parkinson Disease
Compulsive Personality Disorder
Obsessive-Compulsive Disorder
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases
Personality Disorders
Mental Disorders
Anxiety Disorders processed this record on August 22, 2017