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Development of Population Norms of the Computerized Neuropsychological Assessment for Effectiveness of the Antipsychotic Treatment in Schizophrenia

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified November 2008 by BeerYaakov Mental Health Center.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00789906
First Posted: November 13, 2008
Last Update Posted: November 13, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
BeerYaakov Mental Health Center
  Purpose

Schizophrenia affects cognition, emotion, and behavior. Neuropsychological assessment enables a better understanding of antipsychotic effectiveness and the brain processes, underlying cognitive functioning in schizophrenia.

Neurocognitive deficits in schizophrenia patients appears to explain up to 61% of the variance of functional outcome and is an important predictor of social reintegration (Peuskens et al, 2005) and independent living activitiy (Green et al, 2004). Impaired social functioning within schizophrenia population has been associated with increased health-care costs. Since social and occupational disability may generate the largest indirect costs of the illness, treatment of cognitive deficits has an enormous impact on the cost and disability associated with schizophrenia (McGurk and Mueser, 2004).

However, the gap between cognitive science and clinical practice limits the implementation of cognitive assessment in the routine evaluation of schizophrenia patients. Pharmaceutical industry initiated numerous large scale, multisite studies on the impact of novel antipsychotics on cognitive deficits in schizophrenia patients.

The aim of this research is to develop population norms of the computerized neuropsychological assessment for effectiveness of the antipsychotic treatment in schizophrenia.


Condition
Schizophrenia

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Development of Population Norms of the Computerized Neuropsychological Assessment for Effectiveness of the Antipsychotic Treatment in Schizophrenia

Resource links provided by NLM:


Further study details as provided by BeerYaakov Mental Health Center:

Estimated Enrollment: 700
Study Start Date: July 2008
Groups/Cohorts
1
350 healthy women , aged from 18 to 89
2
350 healthy men, aged from 18 to 89

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 89 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
700 healthy adults (350 women and 350 men, aged from 18 to 89)
Criteria

Inclusion Criteria:

  • An IQ, which is within normal range.

Exclusion Criteria:

  • Psychiatric co-morbidity.
  • Physical disability or illness.
  • A history of severe head injury.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00789906


Contacts
Contact: Semyon Kertzman, MD 972-8-9776136 research@beerness.health.gov.il

Locations
Israel
Beer-Yaacov MHC Recruiting
Beer Yaacov, Israel, 70350
Contact: Kertzman    972-8-9776136    research@beerness.health.gov.il   
Principal Investigator: Semion Kertzman, M.D.         
Sponsors and Collaborators
BeerYaakov Mental Health Center
  More Information

Responsible Party: Semion Kertzman, BeerYaakov Mental Health Center
ClinicalTrials.gov Identifier: NCT00789906     History of Changes
Other Study ID Numbers: 223CTIL
First Submitted: November 11, 2008
First Posted: November 13, 2008
Last Update Posted: November 13, 2008
Last Verified: November 2008

Keywords provided by BeerYaakov Mental Health Center:
Computerized Neuropsychological Assessment
Development of Population Norms of the Computerized Neuropsychological Assessment

Additional relevant MeSH terms:
Schizophrenia
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders
Antipsychotic Agents
Tranquilizing Agents
Central Nervous System Depressants
Physiological Effects of Drugs
Psychotropic Drugs