Gastrointestinal Motility in Patients With Neuroendocrine Tumors
We will study the total gastrointestinal transit time (GITT), gastric emptying and small intestine motility in NET patients before and after treated with somatostatin analogues and compare these to healthy subjects. For this we will use radio-opaque markers and the newly developed Motility Tracking System (MTS).
Hypothesis: Patients with NET and carcinoid syndrome have decreased GITT, gastric emptying and small bowel transit time and an increase in phase III MMC activity compared to healthy subjects. Treatment with somatostatin analogues increase transit times and decrease phase III MMC activity and improves the clinical symptoms.
|Neuroendocrine Tumor||Device: Magnetic Tracking System (MTS) and radio-opaque markers|
|Official Title:||Gastrointestinal Motility in Patients With Neuroendocrine Tumors-Effects of Sandostatin LAR|
- Gastrointestinal transit time in NET patients [ Time Frame: End of the study ]
- Gastric emptying in NET patients [ Time Frame: End of the study ]
- Small intestinal transit time [ Time Frame: End of the study ]
- Small intestinal velocity [ Time Frame: End of the study ]
- Changes in carcinoid symptoms and biomarkers [ Time Frame: End of the study ]
Biospecimen Retention: Samples With DNA
|Study Start Date:||September 2008|
|Study Completion Date:||May 2010|
|Primary Completion Date:||May 2010 (Final data collection date for primary outcome measure)|
|Patients with NET and diarrhea.||
Device: Magnetic Tracking System (MTS) and radio-opaque markers
MTS: A small magnetic pill (6x15mm) is swallowed by the patient and the movement of this pill is registered by a sensor (coordinates x,y,z angles θ, φ) and depicted af graphs on a computer screen. For determination of GITT a capsule containing 10 radio-opaque markers is ingested every day for six days, on day seven an abdominal x-ray is performed.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00789841
|Analfysiologisk afsnit, Aarhus University Hospital, Tage Hansensgade, entrance 11A|
|Aarhus, Denmark, 8000|