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Analysis of Cortical Excitability in Neuropathic Pain

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2010 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
Information provided by:
National Taiwan University Hospital Identifier:
First received: November 10, 2008
Last updated: April 1, 2010
Last verified: March 2010
The purpose of this study is to determine whether patients with neuropathic pain has abnormal excitability in somatosensory cortex and abnormal sensory-motor connections.

Neuropathic Pain
Cortical Excitability

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Analysis of Cortical Excitability in Neuropathic Pain: an Electrophysiology Study.

Further study details as provided by National Taiwan University Hospital:

Primary Outcome Measures:
  • Abnormal cortical excitability in motor-sensory cross-talk [ Time Frame: non-applicable ]

Secondary Outcome Measures:
  • Genetic variability of neurotrophic factors between groups [ Time Frame: non-applicable ]

Biospecimen Retention:   Samples With DNA
Genomic polymorphism of neurotrophic factors.

Estimated Enrollment: 80
Study Start Date: October 2008
Estimated Study Completion Date: October 2011
Estimated Primary Completion Date: October 2011 (Final data collection date for primary outcome measure)
Healthy volunteers
Patient with neuropathic pain
patients without neuropathic pain

Detailed Description:

There are several brain areas responsible for neuropathic pain reported in functional image studies, including primary sensory cortex, insula, and anterior cingulate gyrus. However, it is few informations about the functional status of these areas. Besides, the reason of the individual variability about the developement of neuropathic pain remains unknown. It is lack of satisfactory explanation about why some people developed neuropathic pain in certain diseased situation (for example, type 2 diabetes), while others do not.

We hypothesis that patients with neuropathic pain has abnormal cortical excitability and plasticity in certain brain area. Therefore developed neuropathic pain certain diseased condition while others not. Therefore, we will use multimodal electrophysiology tools,such as transcranial magnetic stimulation, peripheral nerve stimulation, and contact heat evoke potential to monitor the cortical excitability and plasticity non-invasively.


Ages Eligible for Study:   20 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Primary care clinic healthy volunteer

Inclusion Criteria:

  • Healthy volunteers
  • patients with pain resulted from dysfunction of peripheral or central nervous system
  • the disorders of peripheral nerves are diagnosed by nerve conduction study, quantitative sensory test, quantification of skin innervation or contact heat evoked potentials
  • lesion of central nervous system should be confirmed by neuroimage.

Exclusion Criteria:

  • previous history of epilepsy, seizure disorders or major head injury
  • previous brain surgery or intracranial metalic implant
  • implanted devices as cardiac pacemaker
  • pregnant subjects
  • patient with severe cardiac or pulmonary disease who potentially cannot tolerate stress
  Contacts and Locations
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Please refer to this study by its identifier: NCT00789347

Contact: Ming-Kai Pan, M.D. 886-2-23123456 ext 9803397
Contact: Ch-Chao Chao, M.D. 886-2-23123456 ext 9801967

National Taiwan University Hospital Recruiting
Taipei, Taiwan, 100
Contact: Ming-Kai Pan, M.D.    886-2-23123456 ext 9803397   
Contact: Chi-Chao Chao, M.D.    886-2-23123456 ext 9801967   
Sub-Investigator: Ming-Kai Pan, M.D.         
Principal Investigator: Sung-Tsang Hsieh, M.D. PhD         
Sub-Investigator: Chi-Chao Chao, M.D.         
Sponsors and Collaborators
National Taiwan University Hospital
Study Director: Ming-Kai Pan, M.D. National Taiwan University Hospital, Department of Neurology
Study Director: Chi-Chao Chao, M.D. National Taiwan University Hospital, Department of Neurology
Principal Investigator: Sung-Tsang Hsieh, M.D. PhD National Taiwan University Hospital, Department of Neurology
  More Information

Responsible Party: Sung-Tsang Hsieh/ MD. PHD., National Taiwan University, Department of Neurology Identifier: NCT00789347     History of Changes
Other Study ID Numbers: 200806061R
Study First Received: November 10, 2008
Last Updated: April 1, 2010

Keywords provided by National Taiwan University Hospital:
Neuropathic pain
Cortical excitability
Transcranial magnetic stimulation
Contact Heat evoked potential
peripheral nerve stimulation
neurotrophic factors

Additional relevant MeSH terms:
Neurologic Manifestations
Nervous System Diseases
Peripheral Nervous System Diseases
Neuromuscular Diseases
Signs and Symptoms processed this record on April 28, 2017