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Myocilin Variations and Familial Glaucoma in Taxiarchis (Taxiarchis)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2014 by Aristotle University Of Thessaloniki.
Recruitment status was:  Recruiting
Information provided by (Responsible Party):
AGP Konstas, Aristotle University Of Thessaloniki Identifier:
First received: November 7, 2008
Last updated: May 9, 2014
Last verified: May 2014
Taxiarchis, a small village in Northern Greece with 1060 inhabitants, was considered to have a surprisingly high incidence of glaucoma. This isolated population located on Mount Holomondas appeared to be enriched for familial glaucoma. Based upon the high reported incidence of glaucoma in Taxiarchis and previous findings of the Thr377Met myocilin mutation in the Greek population,the investigators undertook a community-based study to determine if this variant was present in this village.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Myocilin Variations and Familial Glaucoma in Taxiarchis, A Small Greek Village.

Resource links provided by NLM:

Further study details as provided by Aristotle University Of Thessaloniki:

Primary Outcome Measures:
  • Examining all of the villagers to determine the actual incidence of glaucoma in Taxiarchis and identify the Thr377Met myocilin mutation in glaucoma patients. [ Time Frame: 4 years ]

Biospecimen Retention:   Samples With DNA
Myocilin screening was performed from blood or saliva specimens taken from the village. The promoter region and exons 1-3 of myocilin were sequenced at the Portland Veterans Administration Medical center. Microsatellite marker analysis in the GLC1A region, including D1S452, D1S1619, D1S2790 and D1S242 was performed at deCODE (Reykjavik, Iceland).

Estimated Enrollment: 800
Study Start Date: August 2007
Estimated Study Completion Date: December 2016
Estimated Primary Completion Date: June 2016 (Final data collection date for primary outcome measure)
Villagers in Taxiarchis


Ages Eligible for Study:   1 Year to 90 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Villagers from Taxiarchis

Inclusion Criteria:

  • Individuals born in Taxiarchis

Exclusion Criteria:

  • Individuals that have not been born in Taxiarchis
  Contacts and Locations
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Please refer to this study by its identifier: NCT00788762

Contact: Anastasios G Konstas, MD, PhD 2310-994774
Contact: Georgios Moumtzis, MD 2310-994742

Taxiarchis village Recruiting
Polygyros, Halkidiki, Greece
Sub-Investigator: Antonios Dimopoulos, MD         
Sponsors and Collaborators
Aristotle University Of Thessaloniki
Principal Investigator: Anastasios G Konstas, MD, PhD Glaucoma Unit, 1st University Dept
  More Information

Responsible Party: AGP Konstas, Professor in Ophthalmology, Aristotle University Of Thessaloniki Identifier: NCT00788762     History of Changes
Other Study ID Numbers: A6798
Study First Received: November 7, 2008
Last Updated: May 9, 2014

Keywords provided by Aristotle University Of Thessaloniki:

Additional relevant MeSH terms:
Ocular Hypertension
Eye Diseases processed this record on May 22, 2017