Use of Nitric Oxide Metabolites for Predicting Embryo Quality in In-Vitro Fertilization (IVF)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00788619|
Recruitment Status : Terminated (difficulty with recruitment)
First Posted : November 11, 2008
Last Update Posted : December 11, 2017
|Condition or disease||Intervention/treatment||Phase|
|Infertility||Procedure: Transfer of embryos on day 3 or day 5 after fertilization. Procedure: Day 5 transfer||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||2 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Use of Nitric Oxide Metabolites for Predicting Embryo Quality in In-Vitro Fertilization|
|Actual Study Start Date :||January 2009|
|Actual Primary Completion Date :||October 2009|
|Actual Study Completion Date :||October 2009|
Active Comparator: Day 3 transfer
Subjects in this arm will have two embryos transferred three days after fertilization. Embryos will be selected based on the concentration of nitric oxide metabolites in the culture medium.
Procedure: Transfer of embryos on day 3 or day 5 after fertilization.
Subjects will be allocated at random to the two arms. Group 1 will have two embryos transferred on day 3 based on nitric oxide concentration. Group 2 will have two embryos transferred on day 5 based on morphologic criteria.
Active Comparator: Day 5 transfer
Subjects will have two embryos transferred on day 5 after fertilization with selection of embryos based on morphologic criteria.
Procedure: Day 5 transfer
Subjects will have embryo transfer on day 5 after fertilization. Selection of embryos to transfer will be based on morphologic criteria.
- Percentage of subjects with viable pregnancy one month after embryo transfer [ Time Frame: 1 month ]
- Percentage of subjects with > 2 viable embryos one month after embryo transfer [ Time Frame: 1 month ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00788619
|United States, Maryland|
|Johns Hopkins Fertility Center|
|Lutherville, Maryland, United States, 21093|
|Principal Investigator:||Lisa A Kolp, M.D.||Johns Hopkins University|