Analysis of Immunological Reactions to Foods in Birch Pollen-Allergic Patients
|ClinicalTrials.gov Identifier: NCT00787631|
Recruitment Status : Unknown
Verified October 2008 by Medical University of Vienna.
Recruitment status was: Not yet recruiting
First Posted : November 7, 2008
Last Update Posted : November 7, 2008
A high number of birch pollen-allergic individuals develop hypersensitivity reactions to certain foods, e.g. apples. This food allergy is due to immunological cross-reactivity. Birch pollen-related foods contain proteins, e.g. Mal d 1 in apple, that are structurally related with the major birch pollen allergen, Bet v 1. Hence IgE antibodies and T lymphocytes specific for Bet v 1 recognize these food proteins which results in activation of the immune system and, consequently, in clinical symptoms.
In the present study the investigators intend to investigate if and how the consumption of birch pollen-related food allergens affects birch pollen allergy. In other words, the investigators are interested to analyse whether Bet v 1-related food allergens activate Bet v 1-specific memory cells and thus, contribute to the maintenance of the pollen allergy outside the pollen season. Data obtained in this study will help to clarify the immunological and clinical role of cross-reactivity between pollen and food allergies and will reveal whether avoidance of such foods should be recommended for the patients. Finally, novel approaches for diagnosis and therapy of pollen-related food allergens can be developed.
|Condition or disease|
|Allergic Rhinitis Food Allergy|
|Study Type :||Observational|
|Estimated Enrollment :||30 participants|
|Official Title:||Analysis of Immunological Reactions to Pollen-Related Foods in Birch Pollen-Allergic Patients|
|Study Start Date :||December 2008|
|Estimated Primary Completion Date :||January 2010|
|Estimated Study Completion Date :||December 2010|
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00787631
|Contact: Tamar Kinaciyan, Ass.Prof.MD||+43140400 ext firstname.lastname@example.org|
|Contact: Barbara Bohle, AssocProf Dr||+43140400 ext email@example.com|
|Principal Investigator:||Tamar Kinaciyan, Ass Prof MD||Dept. of Dermatology, Medical University of Vienna|