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Mitochondria and Metabolic Syndrome in a Southern California Chinese Cohort

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00786721
First Posted: November 6, 2008
Last Update Posted: February 10, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Beckman Laser Institute University of California Irvine
Information provided by (Responsible Party):
Beckman Laser Institute and Medical Center, University of California, Irvine
  Purpose
There has been increasing support for our hypothesis that mitochondrial dysfunction plays an important role in the etiology of Type 2 Diabetes Mellitus and the overlapping Metabolic Syndrome.

Condition Intervention
Metabolic Syndrome Type 2 Diabetes Mellitus Device: Diffuse Optical Spectroscopy

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Diffuse Optical Spectroscopy Measurement Technique is Helping Develop More Effective Diagnostic Tools and Therapeutic Regimes for Diabetes, Metabolic Syndrome and Other Mitochondrial Diseases Some Time in the Future

Resource links provided by NLM:


Further study details as provided by Beckman Laser Institute and Medical Center, University of California, Irvine:

Primary Outcome Measures:
  • Near Infrared Spectroscopy to assess muscle mitochondrial OXPHOS function. [ Time Frame: 4 weeks ]

Enrollment: 9
Study Start Date: November 2006
Study Completion Date: August 2010
Primary Completion Date: August 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Diffuse Optical Spectroscopy
muscle properties scanning
Device: Diffuse Optical Spectroscopy
muscle properties scanning

Detailed Description:

Once the mitochondrial defect(s) of these subjects has been defined, the data will be used to develop two non-invasive screening tools to detect mitochondrial defects in Diabetes Mellitus and Metabolic Syndrome patients.

The device call Diffuse Optical Spectroscopy develope at Beckman Laser Instituteis is non-invasive measurement technique, to measure the properties of the muscle tisuue and vascular activity (calf, bicep, or the brain)to evaluate the patient's metabolic status and and to assess muscle mitochondrial OXPHOS function.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
primary care clinic, community sample, residents in a Southern California Chinese Cohort
Criteria

Inclusion Criteria:

  • Chinese descent and have been clinically diagnosed with diabetes mellitus (DM) or have met the study criteria for metabolic syndrome (MS).

Exclusion Criteria:

  • non chiness descent
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00786721


Locations
United States, California
Beckman Laser Institute Medical clinic
Irvine, California, United States, 92612
Sponsors and Collaborators
University of California, Irvine
Beckman Laser Institute University of California Irvine
Investigators
Principal Investigator: Bruce J Tromberg, PhD Beckman Laser Institute University of California Irvine
Principal Investigator: Douglas c Wallace, PhD UCI, Molecular and Mitochondrial medicine and Genetics
  More Information

Responsible Party: Beckman Laser Institute and Medical Center, Virginia Kimonis, MD, MRCP, University of California, Irvine
ClinicalTrials.gov Identifier: NCT00786721     History of Changes
Other Study ID Numbers: NIH-LAMMP-2002-2608
First Submitted: November 4, 2008
First Posted: November 6, 2008
Last Update Posted: February 10, 2017
Last Verified: February 2017

Keywords provided by Beckman Laser Institute and Medical Center, University of California, Irvine:
Mitochondria and Metabolic Syndrome

Additional relevant MeSH terms:
Syndrome
Diabetes Mellitus
Diabetes Mellitus, Type 2
Metabolic Syndrome X
Disease
Pathologic Processes
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Insulin Resistance
Hyperinsulinism