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Animal studies showed that controlled mechanical ventilation (CMV) can induce dysfunction of the diaphragm, resulting in an early-onset and progressive decrease in diaphragmatic force-generating capacity, called ventilator-induced diaphragmatic dysfunction (VIDD).
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Ages Eligible for Study:
18 Years to 85 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Intubated patients in intensive care unit
Invasive mechanical ventilation (tracheally intubated or tracheotomized) less than 48h.·
Duration of mechanical ventilation for at least 72h.·
Subject itself or its next of kin has given written informed consent
Patient is less than 18 years or more than 85 years of age·
The attending physician refuses to allow enrollment·
The patient refuses informed consent
Next of kin is unavailable or refuses informed consent·
Pregnant or breast-feeding female.
A pregnancy test will be performed in all female patients less than 60 years of age.·
Any contraindication to use cervical magnetic stimulation (mechanical cardiac assist device …).·
Presence or suspicion of prior diaphragm injury or chronic disease·
Presence or suspicion of a central nervous system (CNS) disorder, including (but not limited to): CNS infarction, bleeding, tumor, or infection