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Imaging Cardiac Electrical Remodeling With Electrocardiogram Imaging (ECGI)

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ClinicalTrials.gov Identifier: NCT00785564
Recruitment Status : Unknown
Verified November 2008 by Washington University School of Medicine.
Recruitment status was:  Recruiting
First Posted : November 5, 2008
Last Update Posted : November 5, 2008
Sponsor:
Information provided by:
Washington University School of Medicine

Brief Summary:
A consequence of chronic RV pacing is a process of electrical remodeling that alters myocardial repolarization to reflect the altered depolarization induced by the RV lead. When RV pacing is discontinued, the altered repolarization persists for several weeks. This phenomena is traditionally described as "T-wave memory" based upon the 12-lead ECG appearance of inverted T-Waves. The investigators are using the ECGI technique to produce three dimensional electroanatomical images of this phenomena in patients with dual chamber pacemakers. Echocardiography will also be used to image the mechanical effects of RV pacing and T-wave memory. The images will show the spatial distribution of altered repolarization and allow us to correlate any mechanical consequences of this phenomena that may exist.

Condition or disease
Sick Sinus Syndrome

Study Type : Observational
Estimated Enrollment : 10 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Imaging Cardiac Electrical Remodeling With ECGI
Study Start Date : November 2007
Estimated Primary Completion Date : November 2009
Estimated Study Completion Date : November 2009

Resource links provided by the National Library of Medicine





Primary Outcome Measures :
  1. ECGI Image [ Time Frame: 1 month after RV pacing ]


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients of a pacemaker clinic
Criteria

Inclusion Criteria:

  • Implanted dual chamber pacemaker for sick sinus syndrome with no history of complete heart block.

Exclusion Criteria:

  • Persistent atrial fibrillation that is not suppressed by medications.

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00785564


Locations
United States, Missouri
Washington University School of Medicine Recruiting
St. Louis, Missouri, United States, 63110
Contact: Mitchell N Faddis, MD PhD    314-454-7772    mfaddis@wustl.edu   
Contact: Yvonne Oconnell    314-454-7851    yoconnel@im.wustl.edu   
Principal Investigator: Mitchell N Faddis, MD PhD         
Sponsors and Collaborators
Washington University School of Medicine
Investigators
Principal Investigator: Mitchell N Faddis, MD PhD Washington University School of Medicine

Responsible Party: Mitchell N. Faddis MD, PhD, Washington University School of Medicine
ClinicalTrials.gov Identifier: NCT00785564     History of Changes
Other Study ID Numbers: 07-0995
First Posted: November 5, 2008    Key Record Dates
Last Update Posted: November 5, 2008
Last Verified: November 2008

Keywords provided by Washington University School of Medicine:
T-wave memory
Sick Sinus Syndrome

Additional relevant MeSH terms:
Sick Sinus Syndrome
Atrial Remodeling
Arrhythmia, Sinus
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Heart Block
Pathologic Processes
Pathological Conditions, Anatomical