Imaging Cardiac Electrical Remodeling With Electrocardiogram Imaging (ECGI)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified November 2008 by Washington University School of Medicine.
Recruitment status was:  Recruiting
Information provided by:
Washington University School of Medicine Identifier:
First received: November 3, 2008
Last updated: November 4, 2008
Last verified: November 2008
A consequence of chronic RV pacing is a process of electrical remodeling that alters myocardial repolarization to reflect the altered depolarization induced by the RV lead. When RV pacing is discontinued, the altered repolarization persists for several weeks. This phenomena is traditionally described as "T-wave memory" based upon the 12-lead ECG appearance of inverted T-Waves. The investigators are using the ECGI technique to produce three dimensional electroanatomical images of this phenomena in patients with dual chamber pacemakers. Echocardiography will also be used to image the mechanical effects of RV pacing and T-wave memory. The images will show the spatial distribution of altered repolarization and allow us to correlate any mechanical consequences of this phenomena that may exist.

Sick Sinus Syndrome

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Imaging Cardiac Electrical Remodeling With ECGI

Resource links provided by NLM:

Further study details as provided by Washington University School of Medicine:

Primary Outcome Measures:
  • ECGI Image [ Time Frame: 1 month after RV pacing ]

Estimated Enrollment: 10
Study Start Date: November 2007
Estimated Study Completion Date: November 2009
Estimated Primary Completion Date: November 2009 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients of a pacemaker clinic

Inclusion Criteria:

  • Implanted dual chamber pacemaker for sick sinus syndrome with no history of complete heart block.

Exclusion Criteria:

  • Persistent atrial fibrillation that is not suppressed by medications.
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Please refer to this study by its identifier: NCT00785564

United States, Missouri
Washington University School of Medicine
St. Louis, Missouri, United States, 63110
Sponsors and Collaborators
Washington University School of Medicine
Principal Investigator: Mitchell N Faddis, MD PhD Washington University School of Medicine
  More Information

Responsible Party: Mitchell N. Faddis MD, PhD, Washington University School of Medicine Identifier: NCT00785564     History of Changes
Other Study ID Numbers: 07-0995 
Study First Received: November 3, 2008
Last Updated: November 4, 2008

Keywords provided by Washington University School of Medicine:
T-wave memory
Sick Sinus Syndrome

Additional relevant MeSH terms:
Sick Sinus Syndrome
Atrial Remodeling
Arrhythmia, Sinus
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Heart Block
Pathologic Processes
Pathological Conditions, Anatomical processed this record on January 23, 2017