Pregabalin for Postoperative Pain in Women Undergoing Breast Cancer Surgery
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We hypothesize that pregabalin will decrease postoperative pain, as measured by the surrogate markers postoperative pain rating scores and postoperative opioid consumption while improving the quality of recovery following breast cancer surgery compared to placebo. The primary outcome will be postoperative pain, measured by a NRS and the quality of recovery score (QoR) in the first 24h postoperative period. Do women undergoing breast cancer surgery with general anesthesia and receiving pregabalin prior to their surgery and 12 hours later have lower NRS and a greater QoR score in the first 24 hours after their surgery than those women who received placebo?
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Ages Eligible for Study:
up to 65 Years (Child, Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
American Society of Anesthesia physical status class I & II
Age ¬< 65 years
Unilateral breast cancer surgery without axillary node dissection (i.e. simple mastectomies and lumpectomies +/- "sentinal" node biopsy)
Known or suspected allergy, sensitivity, or contraindication to pregabalin
Known or suspected allergy to morphine, NSAIDs, acetaminophen or oxycodone
Morbid Obesity (Body Mass Index ≥ 45 kg/m2)
History of a seizure disorder
Current pre-operative therapy with pregabalin, gabapentin, or any opioid
Any other physical or psychiatric condition which may impair their ability to cooperate with postoperative study data collection
CrCl < 60 ml/min [CrCl = 0.85 x ((140 - age) x weight(kg)) / (72 x Cr(mg/dL)))]
Keywords provided by Ronald George, IWK Health Centre:
Pain, Pregabalin, Lyrica, Breast surgery
Additional relevant MeSH terms:
Nervous System Diseases
Signs and Symptoms
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Calcium Channel Blockers
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Central Nervous System Depressants