The Effect of Inhibition of B7-mediated Costimulation on Allergic Airway Inflammation in Mild Atopic Asthmatics (CIA)
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|ClinicalTrials.gov Identifier: NCT00784459|
Recruitment Status : Completed
First Posted : November 4, 2008
Results First Posted : February 5, 2014
Last Update Posted : February 5, 2014
|Condition or disease||Intervention/treatment||Phase|
|Atopic Asthma||Drug: abatacept Drug: Placebo||Phase 2|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||24 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Triple (Participant, Care Provider, Investigator)|
|Primary Purpose:||Basic Science|
|Official Title:||Costimulation Inhibition in Asthma|
|Study Start Date :||October 2008|
|Primary Completion Date :||December 2011|
|Study Completion Date :||February 2012|
Experimental: Treatment with Abatacept
Administration of Abatacept intravenously 10 mg/kg every 2 weeks for 3 doses, followed by every 4 weeks for 2 doses.
Treatment with abatacept, 10 mg/kg IV, for 5 doses.
Placebo Comparator: Placebo
Administration of placebo (normal saline) intravenously 10 mg/kg every 2 weeks for 3 doses, followed by every 4 weeks for 2 doses.
Treatment with Placebo, IV
- Baseline Percentage of Eosinophils Recovered in the BAL Prior to Segmental Allergen Challenge [ Time Frame: baseline ]collected prior to randomization to abatacept or placebo
- Percentage of Eosinophils Recovered Following Segmental Allergen Challenge Following 3 Months of Placebo or Abatacept [ Time Frame: 3 months ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00784459
|United States, Missouri|
|Washington University School of Medicine|
|saint Louis, Missouri, United States, 63110|
|Principal Investigator:||Jonathan Green, MD||Washington University School of Medicine|