Middle and Inner Ear Malformation in Children With Velocardiofacial Syndrome

This study has been completed.
Information provided by:
Pontificia Universidade Catolica de Sao Paulo
ClinicalTrials.gov Identifier:
First received: October 31, 2008
Last updated: NA
Last verified: October 2008
History: No changes posted
Middle and inner ear malformations on two boys with velocardiofacial syndrome are discussed.Special attention should be given to the presence of hearing loss due to middle and inner ear malformations, in addition to frequent conductive hearing loss regarding mastoid and middle ear inflammatory processes.

Ear Malformations in the Velocardiofacial Syndrome

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Middle and Inner Ear Malformation in Children With Velocardiofacial Syndrome

Resource links provided by NLM:

Further study details as provided by Pontificia Universidade Catolica de Sao Paulo:

Enrollment: 2
Study Start Date: January 2007
Study Completion Date: June 2007
Primary Completion Date: March 2007 (Final data collection date for primary outcome measure)
Detailed Description:
Two boys with clinical signs of velocardiofacial syndrome, at ages of 4.7 and 6,7 years old are the subjects of this study.Audiological evaluation, including pure tone audiometry, tympanometry, acoustical reflex, and Computerized Tomography of temporal bones, and analyses of DNA sample with markers of 22q11 region were performed.

Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Children with velocardiofacial syndrome

Inclusion Criteria:

  • Subjects with velocardiofacial syndrome
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00784173

Sponsors and Collaborators
Pontificia Universidade Catolica de Sao Paulo
Principal Investigator: Alfredo Tabith-Junior, MD Pontificia Universidade Católica de São Paulo
  More Information

Responsible Party: Alfredo Tabith Junior, Pontificia Universidade Catolica de São Paulo
ClinicalTrials.gov Identifier: NCT00784173     History of Changes
Other Study ID Numbers: Unique protocol 
Study First Received: October 31, 2008
Last Updated: October 31, 2008
Health Authority: Brazil: National Committee of Ethics in Research

Keywords provided by Pontificia Universidade Catolica de Sao Paulo:
Middle ear
Inner ear

Additional relevant MeSH terms:
Congenital Abnormalities
DiGeorge Syndrome
22q11 Deletion Syndrome
Abnormalities, Multiple
Cardiovascular Abnormalities
Cardiovascular Diseases
Chromosome Disorders
Craniofacial Abnormalities
Endocrine System Diseases
Genetic Diseases, Inborn
Heart Defects, Congenital
Heart Diseases
Lymphatic Abnormalities
Lymphatic Diseases
Musculoskeletal Abnormalities
Musculoskeletal Diseases
Parathyroid Diseases
Pathologic Processes

ClinicalTrials.gov processed this record on May 24, 2016