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Intravenous Administration of Metoprolol Versus Biatrial Pacing in the Prevention of Atrial Fibrillation After Cardiac Surgery

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ClinicalTrials.gov Identifier: NCT00783900
Recruitment Status : Completed
First Posted : November 3, 2008
Last Update Posted : March 3, 2017
Sponsor:
Collaborators:
Information provided by:

Study Description
Brief Summary:
The aim of the study is to compare the effectiviness of biatrial pacing versus intravenous administration of metoprolol in the prevention of atrial fibrillation after cardiac surgery

Condition or disease Intervention/treatment Phase
Atrial Fibrillation Biatrial Pacing Metoprolol Other: metoprolol, biatrial pacing Phase 4

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 316 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Intravenous Metoprolol Versus Biatrial Pacing in the Prevention of Atrial Fibrillation After Cardiac Surgery
Study Start Date : January 2007
Primary Completion Date : December 2009
Study Completion Date : December 2009


Arms and Interventions

Arm Intervention/treatment
Active Comparator: metoprolol Other: metoprolol, biatrial pacing
Prevention, atrial fibrillation, cardiac surgery, biatrial pacing, metoprolol
Active Comparator: biatrial pacing Other: metoprolol, biatrial pacing
Prevention, atrial fibrillation, cardiac surgery, biatrial pacing, metoprolol


Outcome Measures

Primary Outcome Measures :
  1. biatriac pacing [ Time Frame: 48 hours ]
  2. Incidence of atrial fibrillation [ Time Frame: 48 hours ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • elective CABG and aortic valve cardiac patients,
  • previous use of beta blocker

Exclusion Criteria:

  • Previous episodes of Atrial fibrillation or flutter,
  • II or II degree atrioventricular block, uncontrolled heart failure
  • Sick sinus syndrome
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00783900


Locations
Finland
Halonen Jari
Kuopio, Finland, FIN-70211
Sponsors and Collaborators
Kuopio University Hospital
Oulu University Hospital
Hospital Cordia, Kuopio, Finland
More Information

Responsible Party: Halonen Jari, Kuopio university hospital
ClinicalTrials.gov Identifier: NCT00783900     History of Changes
Other Study ID Numbers: KUH5204006
Eudra-CT: 2008-006932-36
First Posted: November 3, 2008    Key Record Dates
Last Update Posted: March 3, 2017
Last Verified: November 2011

Keywords provided by Kuopio University Hospital:
Prevention

Additional relevant MeSH terms:
Atrial Fibrillation
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes
Metoprolol
Anti-Arrhythmia Agents
Antihypertensive Agents
Sympatholytics
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Adrenergic beta-1 Receptor Antagonists
Adrenergic beta-Antagonists
Adrenergic Antagonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action