Low Dose of Midazolam is Superior to Conventional Dose for Rapid Sequence Intubation in Emergency Department (ED)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00783731
Recruitment Status : Completed
First Posted : November 3, 2008
Last Update Posted : July 26, 2011
Information provided by:
Seoul National University Hospital

Brief Summary:
Midazolam has been used in rapid sequence intubation for a long time, and the recommended dose is 0.1mg/kg. In some studies, however, the reduced dose has been used with the concern of hemodynamic instability. We would like to investigate that the low dose midazolam could be used rather than the standard recommended dose, and also compare it to the etomidate, recently used sedatives, with respect to the side effects and the easy performance of intubation.

Condition or disease Intervention/treatment Phase
Intubation Drug: Low dose midazolam Not Applicable

Study Type : Interventional  (Clinical Trial)
Primary Purpose: Treatment
Study Start Date : October 2008
Actual Primary Completion Date : October 2010
Actual Study Completion Date : January 2011

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: Low dose midazolam Drug: Low dose midazolam

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • patients who need rapid sequence intubation in emergency room

Exclusion Criteria:

  • in hypotension(systolic blood pressure less than 90 mmHg
  • severe trauma patients
  • pregnant
  • allergic to midazolam, etomidate

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00783731

Korea, Republic of
Seoul National University Bundang Hospital, Emergency room
Seongnam-si, Gyeonggi-do, Korea, Republic of, 463-707
Boramae Medical Center
Seoul, Korea, Republic of, 156-707
Sponsors and Collaborators
Seoul National University Hospital Identifier: NCT00783731     History of Changes
Other Study ID Numbers: RSI study
First Posted: November 3, 2008    Key Record Dates
Last Update Posted: July 26, 2011
Last Verified: July 2011

Keywords provided by Seoul National University Hospital:

Additional relevant MeSH terms:
Adjuvants, Anesthesia
Hypnotics and Sedatives
Central Nervous System Depressants
Physiological Effects of Drugs
Anti-Anxiety Agents
Tranquilizing Agents
Psychotropic Drugs
Anesthetics, Intravenous
Anesthetics, General
GABA Modulators
GABA Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action