Using Neuroimaging to Investigate Major Depressive Disorder
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The purpose of this neuroimaging study is to investigate the brain correlates of Major Depressive Disorder with anxiety symptoms as well as potentially identify predictors of treatment outcome.
Condition or disease
Major Depressive DisorderDepressionAnxiety
The purpose of this study is to test whether the structural and functional connectivity between the dorso-lateral prefrontal cortex (DLPFC) and amygdala will decline as symptoms of co-morbid anxiety (Anxiety Factor Score) increase in patients with MDD. This decrease in connectivity will also account for decrease in treatment response. The structural connectivity will be assessed using Diffusion Tensor Imaging (DTI) and the functional connectivity will be assessed using resting state BOLD fMRI.We propose to use the fMRI and DTI to identify biological markers that are associated with treatment response in a cohort of patients with a spectrum of Anxiety Factor Scores.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 50 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Competent to give informed consent
Diagnosis of Major Depressive Disorder
Males and females
Ages 18-50 years old
All races and ethnicities
Able to read, speak, and understand English*
History of psychiatric illness except Major Depressive Disorder, Generalized Anxiety Disorder, Social Phobia, or Specific Phobia
Alcohol or substance abuse within the last 6 months or alcohol or substance dependence within the last year
Diagnosis of an organic brain disease
Serious unstable medical illness
History of serious head injury
Unsafe or unable to have an MRI or previous inability to tolerate MRI