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Effects of a Peripheral Nerve Block on Biomarkers of Pain and Inflammation

This study has been completed.
Information provided by:
Stanford University Identifier:
First received: October 24, 2008
Last updated: November 21, 2008
Last verified: November 2008
The purpose of this study is to determine the effect of a local anesthetic nerve block on markers of inflammation and pain after a sunburn. This is important because it may provide information regarding the way that nerve blocks help with the treatment of pain and in particular provide preemptive analgesia.

Condition Intervention
Procedure: femoral nerve block

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double-Blind
Primary Purpose: Prevention
Official Title: Effect of Peripheral Nerve Block on Inflammatory and Nociceptive Biomarkers in a UV-B Burn Model in Humans

Further study details as provided by Stanford University:

Primary Outcome Measures:
  • Measurement of the effect of a preemptive peripheral nerve block on the hyperalgesic response to an artificially induced sunburn.

Secondary Outcome Measures:
  • Measurement of the effect of a preemptive peripheral nerve block on the release of pro-inflammatory cytokines.

Estimated Enrollment: 15
Study Start Date: October 2007
Estimated Study Completion Date: July 2008

Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Inclusion Criteria:1. Between 18 and 50 years of age 2. Fluent in English language 3. Provide written informed consent 4. Skin pigmentation type II or III
 Exclusion Criteria:1. Current use of prescription drugs interfering with study objective 2. Use of over-the-counter analgesic/anti-inflammatory drugs within 48h of study participation 3. Current acute or chronic pain conditions 4. Significant medical conditions including psychiatric, neurological, and dermatological diseases 5. Pregnancy 6. Allergies to study drug(s) 7. Concomitant participation in other study protocol
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Please refer to this study by its identifier: NCT00780936

United States, California
Stanford University School of Medicine
Stanford, California, United States, 94305
Sponsors and Collaborators
Stanford University
Principal Investigator: Martin S Angst Stanford University
  More Information Identifier: NCT00780936     History of Changes
Other Study ID Numbers: SU-01222008-984
eProtocol number 10740
Study First Received: October 24, 2008
Last Updated: November 21, 2008 processed this record on April 26, 2017