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AKIN Criteria: Acute Kidney Injury After On-Pump Coronary Artery Bypass Graft (CABG)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00780845
First Posted: October 28, 2008
Last Update Posted: November 4, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Hospital de Base
  Purpose
The purpose of this study is evaluate clinical outcomes and 30-day mortality after on-pump CABG.

Condition
Kidney Failure

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: AKIN (Acute Kidney Injury Network): Acute Kidney Injury After On-Pump Coronary Artery Bypass Graft Surgery

Resource links provided by NLM:


Further study details as provided by Hospital de Base:

Primary Outcome Measures:
  • To test the hypothesis that patients with acute kidney injury after on-pump CABG have higher 30-day mortality [ Time Frame: 30 days ]

Secondary Outcome Measures:
  • To compare clinical outcomes in patients with and without acute kidney injury after on-pump CABG [ Time Frame: 30 days ]

Enrollment: 817
Study Start Date: January 2003
Study Completion Date: January 2008
Primary Completion Date: January 2008 (Final data collection date for primary outcome measure)
Groups/Cohorts
AKI (-)
Patients without acute kidney injury after on-pump CABG
AKI (+)
Patients with acute kidney injury after on-pump CABG

Detailed Description:
Eight hundred and seventeen patients was enrolled in this series and divided into to groups: Group AKI (-) - patients without acute kidney injury after on-pump CABG. Group AKI (+) - patients with acute kidney injury after on-pump CABG. AKI was defined as an absolute increase in serum creatinine (SCr) of more than or equal to 0.3 mg/dl (≥ 26.4 μmol/l) or a percentage increase in SCr of more than or equal to 50% (1.5-fold from baseline). The change in SCr concentration was defined as the difference between immediate postoperative concentration and the highest concentration during the stay in ICU. Clinical Outcomes and 30-day mortality was evaluate in this patients.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Groups AKI (-) and AKI (+) selected consecutively after admission in cardiac surgery postoperative care unit
Criteria

Inclusion Criteria:

  • Patients underwent on-pump coronary artery bypass grafting
  • Patients with at least two serum creatinine values within 48 hours.

Exclusion Criteria:

  • Patients with end-stage kidney disease requiring renal replacement therapy.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00780845


Sponsors and Collaborators
Hospital de Base
Investigators
Study Director: Lilia N Maia, PhD São José do Rio Preto Medical School
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Mauricio N Machado, São José do Rio Preto Medical School
ClinicalTrials.gov Identifier: NCT00780845     History of Changes
Other Study ID Numbers: CAAE-3438.0.000.140-08
First Submitted: October 27, 2008
First Posted: October 28, 2008
Last Update Posted: November 4, 2008
Last Verified: October 2008

Keywords provided by Hospital de Base:
Acute Kidney failure
Clinical outcomes
On-pump
Coronary artery bypass grafting
Morbidity
Mortality

Additional relevant MeSH terms:
Acute Kidney Injury
Renal Insufficiency
Kidney Diseases
Urologic Diseases