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Study Evaluating the Addition of Sildenafil to Bosentan Therapy in Pulmonary Arterial Hypertension

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ClinicalTrials.gov Identifier: NCT00780728
Recruitment Status : Withdrawn
First Posted : October 28, 2008
Last Update Posted : November 13, 2009
Sponsor:
Information provided by:
University Health Network, Toronto

Brief Summary:
This study will examine the effects of add-on sildenafil to bosentan monotherapy in patients with Pulmonary Arterial Hypertension. Patients on bosentan monotherapy will be followed every 6 months to assess if they have met the pre-defined treatment goals. If a patient fails to achieve these treatment goals or fails to maintain them, sildenafil will be added to their existing bosentan monotherapy. Patients will be assessed 6 months after start of combination therapy for changes in 6MWT, Borg dyspnea scale, WHO functional class, quality of life.

Condition or disease Intervention/treatment Phase
Hypertension, Pulmonary Drug: Sildenafil Phase 3

Study Type : Interventional  (Clinical Trial)
Official Title: Addition of Sildenafil to Bosentan Monotherapy in Patients With Pulmonary Arterial Hypertension (PAH)


Arm Intervention/treatment
Active Comparator: Sildenafil Drug: Sildenafil




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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Criteria
Inclusion & Exclusion Criteria

ClinicalTrials.gov Identifier: NCT00780728     History of Changes
Other Study ID Numbers: UHNOHI
First Posted: October 28, 2008    Key Record Dates
Last Update Posted: November 13, 2009
Last Verified: November 2009

Additional relevant MeSH terms:
Hypertension
Familial Primary Pulmonary Hypertension
Hypertension, Pulmonary
Vascular Diseases
Cardiovascular Diseases
Lung Diseases
Respiratory Tract Diseases
Sildenafil Citrate
Bosentan
Vasodilator Agents
Phosphodiesterase 5 Inhibitors
Phosphodiesterase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Urological Agents
Antihypertensive Agents
Endothelin Receptor Antagonists